Antifungal activity of bioactive constituents and bark extracts of Rhododendron arboreum

  • Muhammad Nisar Institute of Chemical Sciences, University of Peshawar, Peshawar 25120
  • Sajid Ali Institute of Chemical Sciences, University of Peshawar, Peshawar 25120
  • Muhammad Qaisar Medicinal Botanic Center, PCSIR Laboratories Complex, Peshawar 25120
  • Syed Naeemuddin Gilani Medicinal Botanic Center, PCSIR Laboratories Complex, Peshawar 25120
  • Muhammad Raza Shah HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences,University of Karachi, Karachi 75270
  • Inamullah Khan Department of Pharmacy, University of Peshawar, Peshawar 25120
  • Gowhar Ali Department of Pharmacy, University of Peshawar, Peshawar 25120
Keywords: Antifungal activity, Rhododendron arboretum, Triperpenoid

Abstract

Rhododendron arboreum various fractions of bark as well as the isolated compounds were investigated against pathogenic fungi to provide evidence for the folkloric uses reported in the traditional system. Various solvent fractions and compounds were tested using agar well diffusion method at concentrations of 50, 25 and 12.5 mg/mL, the maximum inhibition recorded against fungi 17-32, 15-27 and 10-24 mm for methanol extract, 16-28, 14-26 and 10-22 mm to ethyl acetate extract, 17-21, 8-18 and 10-16 to chloroform extract and 8-15 and 8-12 mm to n-hexane extract respectively. Maximum inhibition at 10, 5 and 2.5 mg/mL of isolated triterpenoids was recorded against such as fungi 28-44, 25-42 and 20-40 mm for 3β-acetoxyurs-11,12-epoxy-13β,28-olide, 23-44, 20-42 and 15-40 mm for betulin and 17-40, 15-37 and 13-34 for lupeol respectively. It is concluded from the present study that the antifungal activity of the extracts may be due to the presence of 3β-acetoxyurs-11,12-epoxy-13β,28 - olide, betulin, lupeol and taraxerol.

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Published
2013-05-11
How to Cite
Nisar, M., S. Ali, M. Qaisar, S. Gilani, M. Shah, I. Khan, and G. Ali. “Antifungal Activity of Bioactive Constituents and Bark Extracts of Rhododendron Arboreum”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, May 2013, pp. 218-22, doi:10.3329/bjp.v8i2.14054.
Section
Research Articles