Pharmacological basis for the medicinal use of Morus alba in gut and airways disorders

  • Munasib Khan Natural Products Research Unit, Department of Biological and Biomedical, Sciences, The Aga Khan University Medical College, Karachi 74800
  • Najeeb-ur -Rehman Natural Products Research Unit, Department of Biological and Biomedical, Sciences, The Aga Khan University Medical College, Karachi-74800
  • Arif-ullah Khan Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000
  • Anwar Hassan Gilani Natural Products Research Unit, Department of Biological and Biomedical, Sciences, The Aga Khan University Medical College, Karachi-74800
Keywords: Airways disorder, Gut, Morus alba


Crude extract of Morus alba at 100 mg/kg exhibited protective effect against castor oil-induced diarrhea in mice. In isolated rabbit jejunum, M. alba (0.3-10 mg/mL) inhibited the spontaneous contractions and caused glibenclamide-sensitive inhibition of low K+ (20 mM)-induced contractions, with mild effect on high K+ (80 mM). Similarly, cromakalim caused inhibition of low K+, but not of high K+, while verapamil did not differentiate in its inhibitory effect on two concentrations of K+. M. alba (3.0-30 mg/kg) caused suppression of carbachol (100 µg/kg)-induced increase in inspiratory pressure of anaesthetized rats. In guinea-pig trachea, M. alba completely inhibited low K+ contractions, with partial effect on high K+. M. alba (0.3-1.0 mg/mL) caused leftward shift of isoprenaline-induced inhibitory concentration response curves, like papaverine. These results indicate that M. alba possesses a combination of KATP channel opening, weak Ca++-antagonist and phosphodiesterase inhibitory mechanisms, which explain its medicinal use in hyperactive gut and airways disorders.


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How to Cite
Khan, M., N.- ur -Rehman, A.- ullah Khan, and A. Gilani. “Pharmacological Basis for the Medicinal Use of Morus Alba in Gut and Airways Disorders”. Bangladesh Journal of Pharmacology, Vol. 7, no. 4, Dec. 2012, pp. 289-98, doi:10.3329/bjp.v7i4.12873.
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