Effect of Aralia chinensis on serum TNF-a, IL-4 and IL-10 level in rats with adjuvant-induced arthritis
Our study investigated the effect of Aralia chinensis on serum tumor necrosis factor-α (TNF-α), Interleukins (IL-4, IL-10) in rats with adjuvant-induced arthritis. Adjuvant-induced arthritis rats had more slowly increased body weight, dramatically increased TNF-α level but reduced IL-4, IL-10 levels compared with control group. A. chinensis, Tripterygium wilfordii and control group had significantly increased body weight, IL-4, IL-10, and markedly reduced arthritis index and TNF-α level compared with the adjuvant-induced arthritis group. A. chinensis and T. wilfordii group had significantly increased IL-4 and IL-10 levels and markedly reduced TNF-α level compared with control group. A. chinensis could significantly increase the IL-4 level compared with the control group and it can balance the cytokines in arthritis rats, which attributes to the improvement of adjuvant induced arthritis.
Gonzalez-Rey E, Chorny A, Varela N, O'Valle F, Delgado M. Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells. Arthritis Rheum. 2007; 56: 531-43.
Murdoch C, Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood 2000; 95: 3032-43.
Palmer G, Guerne PA, Mezin F, Maret M, Guicheux J, Goldring MB, Gabay C. Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis Res. 2002; 4: 226-31.
Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994; 76: 301-14.
Wang TG, Chen WF. Advance in biological effect of interleukin-4. Foreign Med Sci (Section Immunol). 1994; 1: 13-16.
Wang Y, Zhu Z, Wang C, Yang J. [Determination of oleanolic acid and total saponins in Aralia L]. [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 1998; 23: 518-21, 574.
Wang Z, Tang H, Su Z, Tan M, Hu J, Li C, Yi Y. [Resources survey of medicinal species from genus Aralia]. [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 1997; 22: 3-6, 60.
Yu SS. Clinical significance of measurements of changes of serum IL-2, SIL-2R and TNF-? levels after treatment in patients with rheumatoid arthritis. J Radioimmunol. 2007; 20: 231-33.
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