Effect of Aralia chinensis on serum TNF-a, IL-4 and IL-10 level in rats with adjuvant-induced arthritis

  • Lei Yi Department of Traditional Chinese Medicine, Shaanxi Provincial People’s Hospital, Xi’an
  • Jianjun Feng Department of Geriatric Neurology, Second Affiliated Hospital of Medical Collage of Xi’an Jiaotong University, Xi’an
  • Haiwang Ji Department of Traditional Chinese Medicine, Shaanxi Provincial People’s Hospital, Xi’an
  • Xuechong Zhang Department of Traditional Chinese Medicine, Shaanxi Provincial People’s Hospital, Xi’an
Keywords: Adjuvant-induced arthritis, Aralia chinesis, IL-10, IL-4, Rat, TNF-a

Abstract

Our study investigated the effect of Aralia chinensis on serum tumor necrosis factor-α (TNF-α), Interleukins (IL-4, IL-10) in rats with adjuvant-induced arthritis. Adjuvant-induced arthritis rats had more slowly increased body weight, dramatically increased TNF-α level but reduced IL-4, IL-10 levels compared with control group. A. chinensis, Tripterygium wilfordii and control group had significantly increased body weight, IL-4, IL-10, and markedly reduced arthritis index and TNF-α level compared with the adjuvant-induced arthritis group. A. chinensis and T. wilfordii group had significantly increased IL-4 and IL-10 levels and markedly reduced TNF-α level compared with control group. A. chinensis could significantly increase the IL-4 level compared with the control group and it can balance the cytokines in arthritis rats, which attributes to the improvement of adjuvant induced arthritis.   

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Published
2012-12-10
How to Cite
Yi, L., J. Feng, H. Ji, and X. Zhang. “Effect of Aralia Chinensis on Serum TNF-A, IL-4 and IL-10 Level in Rats With Adjuvant-Induced Arthritis”. Bangladesh Journal of Pharmacology, Vol. 7, no. 4, Dec. 2012, pp. 285-8, doi:10.3329/bjp.v7i4.12725.
Section
Research Articles