Physico-chemical studies and evaluation of diuretic activity of Cucurbita maxima

  • Venkattapuram Sampath Saravanan Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 638112, Tamilnadu
  • Sellimuthu Manokaran Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 638112, Tamilnadu
Keywords: Cucurbita maxima, Diuretic activity, Physico-chemical parameters.

Abstract

In this study physico-chemical nature and diuretic activity was evaluated to establish the purity and diuretic activity by comparing with the standard acetazolamide. Pulp of Cucurbita maxima is a common cost effective Indian dish, rich in nutrients. Physico-chemical parameters like ash values, extractive values and loss on drying were performed to find the purity. The hydro-alcoholic extract was prepared by extracting the powder in soxhlet apparatus for 36 hrs. The laboratory qualitative analysis was done and constituents like carbohydrates, proteins, lipids, flavonoids, alkaloids and vitamin C were found. The two doses of extract (150 and 300 mg/kg) were given to the rats. Group I served as control, Group II served as standard and Group III and IV served as test. Electrolytes and urine volume was measured after 5 hrs of treatment and the same was compared with the control and the standard drug acetazolamide. Physico-chemical parameters were in the limit and the extract shows significant (p<0.01) diuretic activity at the dose of 300 mg/kg when compared with control.

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Author Biography

Venkattapuram Sampath Saravanan, Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 638112, Tamilnadu

Professor and Head

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Published
2012-12-01
How to Cite
Saravanan, V., and S. Manokaran. “Physico-Chemical Studies and Evaluation of Diuretic Activity of Cucurbita Maxima”. Bangladesh Journal of Pharmacology, Vol. 7, no. 4, Dec. 2012, pp. 277-80, doi:10.3329/bjp.v7i4.12497.
Section
Research Articles