Physico-chemical studies and evaluation of diuretic activity of Cucurbita maxima
DOI:
https://doi.org/10.3329/bjp.v7i4.12497Keywords:
Cucurbita maxima, Diuretic activity, Physico-chemical parameters.Abstract
In this study physico-chemical nature and diuretic activity was evaluated to establish the purity and diuretic activity by comparing with the standard acetazolamide. Pulp of Cucurbita maxima is a common cost effective Indian dish, rich in nutrients. Physico-chemical parameters like ash values, extractive values and loss on drying were performed to find the purity. The hydro-alcoholic extract was prepared by extracting the powder in soxhlet apparatus for 36 hrs. The laboratory qualitative analysis was done and constituents like carbohydrates, proteins, lipids, flavonoids, alkaloids and vitamin C were found. The two doses of extract (150 and 300 mg/kg) were given to the rats. Group I served as control, Group II served as standard and Group III and IV served as test. Electrolytes and urine volume was measured after 5 hrs of treatment and the same was compared with the control and the standard drug acetazolamide. Physico-chemical parameters were in the limit and the extract shows significant (p<0.01) diuretic activity at the dose of 300 mg/kg when compared with control.
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References
Caili FU, Shi Huan, Quanhong LI. A review on pharmacological activities and utilization technologies of pumpkin. Plant Foods Hum Nutr. 2006; 61: 73-80.
Chandra Kalyan Reddy Y, Sandya L, Sandeep D, Salomi KR, Nagarjuna S, Reddy YP. Evaluation of diuretic activity of aqueous and ethanolic extracts of Lawsonia inermis leaves in rats. Asian J Plant Sci Res. 2011; 1: 28-33.
Chaudhri RD. Herbal drugs industry: A practical approach to industrial pharmacognosy. 1st ed. New Delhi, Eastern Publishers, 1996: 505-06.
De Stevens G. Diuretics: Chemistry and pharmacology. 1st ed. New York, Academic Press, 1963, pp 2-7, 52-58.
Divakar MC. Plant drug evaluation: A laboratory guide. 2nd ed. Coimbatore, CD Remedies, 2005, pp 42-45.
Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo ZG. Medicinal plants in therapy: Bull World Health Org. 1985; 63: 8397.
Hancock RD, Haupt S, Viola R. Synthesis of l-ascorbic acid in phloem. Plant Biol. 2003; 3: 1-13.
Harbone JB. Phytochemical methods. 3rd ed. New Delhi, Springer (India) Pvt Ltd, 1998 pp 4-6.
Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed. India, Oriental Enterprises, 2003, pp 1606-08.
Modi DC, Patel JK, Shah BN, Nayak BS. Pharmacognostic studies of the seed of syzygium cumini Linn. Int J Pharm Sci. 2010; 1: 20-26.
Nawirska-Olsza?ska A, Biesiada A, Sokó?-??towska A, Kucharska AZ. Content of bioactive compounds and antioxidant capacity of pumpkin puree enriched with Japanese quince, cornelian cherry, strawberry and apples. Acta Sci Pol Technol Aliment. 2011; 10: 51-60.
Parial S, Jain DC, Joshi SB. Diuretic activity of the extracts of Limonia Acidissima in rats. Rasayan J Chem. 2009; 2: 53-56.
Tadmor Y, Paris HS, Meir A, Schaffer AA, Lewinsohn E. Dual role of pigmentation gene B in affecting carotenoids and vitamin E content in squash Mesocarp. J Agric Food Chem. 2005; 53: 9759-63.
Thomas S, Patil DA, Patil AG, Chandra N. Pharmacognostic evaluation and physicochemical analysis of Averrhoa carambola L. fruit. J Herb Med Toxicol. 2008; 2: 51-54.
Vanamala U, Elumalai A, Eswaraiah CM, Shaik A. An updated review on diuretic plants- 2012. Int J Pharm Biol Arch. 2012; 3: 29-31.
Sahu VK, Irchhaiya R, Shashi A, Gurjar H. Phytochemical investigation and chromatographic evaluation of the ethanolic extract of whole plant extract of Dendrophthoe falcata (l.f.) Ettingsh. Int J Pharm Sci Res. 2010; 1: 39-45.
Yar MS, Ansari ZH. Synthesis and in vivo diuretic activity of biphenyl Benzothiazole-2-carboxamide derivatives. Acta Pol Pharm- Drug Res. 2009; 66: 387-92.
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