Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice

  • Fayong Gong School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000
  • Fenglin Li Key Laboratory of Metastable Materials Science & Technology, College of Materials Science and Engineering, Yanshan University, Hebei Province 066400
  • Wanming Zhang School of Applied and Chemical Engineering, Xichang College, Sichuan Province, 615000
  • Jing Li School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000
  • Zhong Zhang School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000
Keywords: Alloxan, Flavonoid, Mice, Oxidative stress, Tatary buckwheat

Abstract

The present study was undertaken to evaluate the effects of crude flavonoids from tatary buckwheat (FTB) on alloxan-induced oxidative stress in mice. After induction of diabetes, diabetic mice were randomly divided into four groups: one diabetic control group and three different doses of FTB (100, 200 and 400 mg/kg) treated groups, with non-diabetic mice used as the normal control group. The mice were intragastrically administered once daily for 28 days. Fasting blood glucose (FBG), serum insulin, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA) were measured. The results showed that FTB could significantly reduce FBG levels and MDA contents, and increase serum insulin levels, SOD, GPx and CAT activities. These data suggested that FTB possess hypoglycemic effects and could reduce alloxan-induced oxidative stress in mice. Therefore, FTB might be of use as an antidiabetic drug.

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Published
2012-07-01
How to Cite
Gong, F., F. Li, W. Zhang, J. Li, and Z. Zhang. “Effects of Crude Flavonoids from Tatary Buckwheat on Alloxan-Induced Oxidative Stress in Mice”. Bangladesh Journal of Pharmacology, Vol. 7, no. 2, July 2012, pp. 124-30, doi:10.3329/bjp.v7i2.10993.
Section
Research Articles