Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt
Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thiomii) were isolated from the medicinal plant of Terminalia chebula Retz by culture and sub-culture. The ethyl acetate extract of fungal strains, IR-4, IR-6 and IR-7 inhibited the growth of CaCo-2 colon cancer cell lines in MTT assay with IC50 values of 55, 44 and 67 µg/mL, respectively.
Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, VaigroWolff A, Gray-Goodrich M, Campbell H, Mayo J, Boyd M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst. 1991; 83: 757-66.
Mosmann T, Rapid colorimetric assay for the cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65: 55-63.
Petrini O. Fungal endophytes of tree leaves. In: Microbial Ecology of leaves. New York, Springer-Verlag, 1991, p 179.
Rob T, Rahman M R, Mosihuzzaman M, Rahman K M, Sultana N. J Bangladesh Chem Soc. 2005; 18: 64-69.
Schulz B, Wanke U, Drager S, Aust HJ. Endopytes from herbaceous plants and shrubs: Effectiveness of surface sterilization methods. Mycological Res. 1983; 65: 1447-50.
Shoeb M, Begum S, Mamun MIR, Nahar N. Chemical and biological activity studies of endophytic fungus from Terminali chebula Rezt. J Bangladesh Chem Soc. 2010; 23: 101-07.
Stierie A, Strobel GA. Taxol and taxane production by Taxomyces ancireanae. Science 2003; 260: 214-16.
Strobel G, Daisy B, Castillo U, Harper J. Natural products from endophytic microorganisms. J Nat Prod. 2004; 67: 257-68.
Tan RX, Zou WX. Endophytes: A rich source of functional metabolites. Nat Prod Rep. 2001; 18: 448-59.
Zhang HW, Song YC, Tan RX, Biology and chemistry of endophytes. Nat Prod Rep. 2006; 23: 753-71.
Copyright (c) 2012 Mohammad Shoeb, Paul Kong Thoo-Lin, Nilufar Nahar
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