Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt

  • Mohammad Shoeb Department of Chemistry, University of Dhaka, Dhaka
  • Paul Kong Thoo-Lin School of Pharmacy and Life Science, The Robert Gordon University, Aberdeen
  • Nilufar Nahar Department of Chemistry, University of Dhaka, Dhaka
Keywords: Colon cancer, Cytotoxicity, Endophytic fungus

Abstract

Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thiomii) were isolated from the medicinal plant of Terminalia chebula Retz by culture and sub-culture. The ethyl acetate extract of fungal strains, IR-4, IR-6 and IR-7 inhibited the growth of CaCo-2 colon cancer cell lines in MTT assay with IC50 values of 55, 44 and 67 µg/mL, respectively.

Downloads

Download data is not yet available.
Abstract
1588
Download
633 Read
229

References

Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, VaigroWolff A, Gray-Goodrich M, Campbell H, Mayo J, Boyd M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst. 1991; 83: 757-66.

Mosmann T, Rapid colorimetric assay for the cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65: 55-63.

Petrini O. Fungal endophytes of tree leaves. In: Microbial Ecology of leaves. New York, Springer-Verlag, 1991, p 179.

Rob T, Rahman M R, Mosihuzzaman M, Rahman K M, Sultana N. J Bangladesh Chem Soc. 2005; 18: 64-69.

Schulz B, Wanke U, Drager S, Aust HJ. Endopytes from herbaceous plants and shrubs: Effectiveness of surface sterilization methods. Mycological Res. 1983; 65: 1447-50.

Shoeb M, Begum S, Mamun MIR, Nahar N. Chemical and biological activity studies of endophytic fungus from Terminali chebula Rezt. J Bangladesh Chem Soc. 2010; 23: 101-07.

Stierie A, Strobel GA. Taxol and taxane production by Taxomyces ancireanae. Science 2003; 260: 214-16.

Strobel G, Daisy B, Castillo U, Harper J. Natural products from endophytic microorganisms. J Nat Prod. 2004; 67: 257-68.

Tan RX, Zou WX. Endophytes: A rich source of functional metabolites. Nat Prod Rep. 2001; 18: 448-59.

Zhang HW, Song YC, Tan RX, Biology and chemistry of endophytes. Nat Prod Rep. 2006; 23: 753-71.

Published
2012-05-09
How to Cite
Shoeb, M., P. Thoo-Lin, and N. Nahar. “Anti-Colon Cancer Activity of Endophytic Fungal Strains from Terminalia Chebula Rezt”. Bangladesh Journal of Pharmacology, Vol. 7, no. 1, May 2012, pp. 47-49, doi:10.3329/bjp.v7i1.10507.
Section
Research Articles