A comparative study of analgesic property of whole plant and fruit extracts of Fragaria vesca in experimental animal models

Lalit Kanodia, Swarnamoni Das

Abstract

The aim of the study was to compare the analgesic activities of ethanolic extract of fruits and whole plant of Fragaria vesca in experimental animal models. The extracts were prepared by percolation method and oral toxicity testing was performed as per OECD guidelines. Analgesic activity was assessed by tail flick method (for central action) and acetic acid-induced writhing test (for peripheral action). Fruit extract, whole plant extract and aspirin showed significant analgesic activity, both central and peripheral, as compared to control (p<0.01). Although fruit extract at dose of 500 mg/kg showed better activity than 250 mg/kg (p<0.05). Analgesic activities of fruit extract 250 mg/kg and whole plant extract 500 mg/kg were almost equivalent while aspirin was most potent among all with significantly greater activities as compared to all the extracts (p<0.05).

Keywords

Analgesic; Fragaria vesca; Percolation; Tail flick; Writhing

Full Text:

PDF

References

Agrawal SS, Paridhavi M. Essentials of crude drugs. In: Herbal drug technology. 1st ed. Hyderabad, India, Universities Press, 2007, pp 583–87.

Alpine strawberry, Fragaria vesca; accessed on 25th May, 2008 at www.superbherbs.net/alpinestrawberry.htm

Campbell WB. Lipid-derived autacoids: Eicosanoids and platelet activating factor. In: Goodman and Gilman’s The pharmacological basis of therapeutics. Gilman AG, Rall TW, Neis AS, Taylor P (eds). 8th ed. New York, Pergamon Press, 1991, pp 607-08.

D’Armour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther. 1941; 72: 74–79.

Extracta liquid-liquid extracts. In: Pharmaceutical formulos. 1st ed. London, England, The Chemist and Druggist, 1950, p 183.

Ghosh MN. Guide to drug doses in experimental animals. In: Fundamentals of experimental pharmacology. 3rd ed. Kolkata, India, Ghosh and Others, 2005a, pp 230-43.

Ghosh MN. Toxicity studies. In: Fundamentals of experimental pharmacology. 3rd ed. Kolkata, India, Ghosh and Others, 2005b, pp 190-97.

Goyal RK. Screening of analgesics. In: Practicals in pharmacology. 6th ed. Ahmedabad, India, Shah Prakashan, 2006, pp 131-33.

Guyton AC, Hall JE. Somatic sensations: Pain, headache and thermal sensations. In: Textbook of medical physiology. 11th ed. Bangalore, India, Prism Books, 2006, pp 598–99.

Hirose K, Jyoyama H, Kojima Y, Eigyo M, Hatakeyama H. Pharmacological properties of 2-[44-(2-triazolyloxy)- phenyl [propionic acid (480156-5)], a new non-steroidal anti-inflammatory agent. Arzeim Forsch/Drug Res. 1984; 34: 280-86.

OECD. In: Acute oral toxicity- Acute oral toxic class method. Guideline 423, (adopted 23/06/1996) Eleventh Addendum to the OECD guidelines for the testing of chemicals, Organization for Economic Co-operation and Development: Paris, 2001, accessed on 21st May, 2007, at http://www.research.murdoch.edu.au/ethics/arec/oraltoxicity.

Phillips R, Foy N. Herbs. London, Pan Books Ltd., 1990, Plants for a future: Edible, medicinal and useful plants for a healthier world. Accessed on 25th May, 2008, at www.pfaf.org/index.htm.

Rao AB, Sisodia P, Sattur PB. Erythrocyte membrane stabilisation by enfenamic acid. Indian J Exp Biol. 1987; 25: 489-90.

Rao KV. Multiple comparison test procedures. In: Biostatistics. Rao KV, Balakrishnan N (eds). 1st ed. New Delhi, Jaypee Brothers Medical Publishers, 1999, pp 273-84.

Witkin LB, Hebner CF, Gaddi F, O’Keefe E, Spilaletta P, Plumer AJ. Pharmacology of 2–amino–indane hydrochloride (SU–8629). A potent non-narcotic analgesic. J Pharmacol Exp Ther. 1961; 133: 400-08.



DOI: http://dx.doi.org/10.3329/bjp.v4i1.1049

Copyright (c) 2009 Lalit Kanodia, Swarnamoni Das

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.