Costunolide: A novel anti-cancer sesquiterpene lactone

  • Azhar Rasul Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041
  • Saima Parveen Department of Chemistry, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100
  • Tonghui Ma Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041
Keywords: Anticancer, Apoptosis, Costunolide, Natural compound, Sesquiterpene lactone

Abstract

Currently an ample interest is found among oncologists to explore anticancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plant-derived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anticancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor cell lines. This review is aimed to summarize the recent researches about costunolide focusing on anti-tumor activity and to lay emphasis on its molecular targets and its mechanisms, which may help the further design and conduct of preclinical and clinical trials.

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Author Biography

Tonghui Ma, Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041
Director

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Published
2012-03-11
How to Cite
Rasul, A., S. Parveen, and T. Ma. “Costunolide: A Novel Anti-Cancer Sesquiterpene Lactone”. Bangladesh Journal of Pharmacology, Vol. 7, no. 1, Mar. 2012, pp. 6-13, doi:10.3329/bjp.v7i1.10066.
Section
Mini Review