Molecular testing in evaluating thyroid nodules
Keywords:
Thyroid cancer, Fine needle aspiration, indeterminate nodules, molecular cytology, mutation.Abstract
The high prevalence of thyroid nodules are due to increased availability of neck ultrasound . FNAC plays a central role to see benign and malignant nodules. About 20% of FNAC results come back as indeterminate nodule (Thy 3A/3F,Thy 4) for which diagnostic hemithyroidectomy or total thyroidectomy is done but ony 10-30% cases ultimately come back as malignant nodules after biopsy leading to unnecessary operation of 70% cases. In these context the recent availability of molecular tests has helped to supplement malignancy risk assessment in lieu of proceeding directly with a strategy of either surveillance or diagnostic surgery.This paper aims to review and compare three main commercially available molecular cytology platforms using in Europe, and USA, Afirma GSC, Thyroseq GC, and ThyGeNEXT + ThyraMIR. Between these tests, with considerations for factors such as cost and processing time. Thyroseq GC is most commonly used provides detailed genomic information and specific management recommendations. ThyGeNEXT + ThyraMIR, though less studied, presents promising results, particularly in miRNA analysis for weak driver mutations. While molecular testing has primarily served diagnostic purposes, advancements in understanding genetic alterations now offer therapeutic implications.
Bangladesh J Otorhinolaryngol 2026; 32(1): 39-44
0
Downloads
Published
How to Cite
Issue
Section
License
Manuscripts submitted for publication in the Bangladesh Journal of Otorhinolaryngology must not have been previously submitted or published. Accepted papers become the permanent property of the Bangladesh Journal of Otorhinolaryngology. By submitting a manuscript, the authors(s) agree that copyrights for their articles are automatically transferred to Bangladesh Journal of Otorhinolaryngology, if and when the articles are accepted for publication.
The use, in this journal, of registered trade names, trade marks, etc. without special acknowledgement does not imply that such names, as defined by the relevant protection laws, be regarded as unprotected, and, thus, free for general use.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
