Microbial Pattern and Antimicrobial Susceptibility of Ludwig’s : Study in a Tertiary Level Hospital in Bangladesh

Authors

  • Monirul Islam Medical Officer, Pabna Sadar Upazila Health Complex, Pabna, Bangladesh
  • Sheikh Nurul Fattah Rumi Professor and Head, Department of ENT and Head-Neck Surgery, Dhaka Medical College & Hospital , Dhaka, Bangladesh.
  • Mohammad Nazrul Islam Assistant Professor, Department of ENT and Head-Neck Surgery, Cox’s Bazar Medical College & Hospital, Cox’s Bazar, Bangladesh.
  • Debbroto Gangguly Registrar, Department of ENT and Head-Neck Surgery, Dhaka Medical College& Hospital, Dhaka, Bangladesh.
  • IM Hashim Reza Assistant Registrar, Department of ENT and Head-Neck Surgery, Dhaka Medical College& Hospital, Dhaka, Bangladesh.
  • SM Rasel Parvez Registrar, Department of ENT and Head-Neck Surgery, Shaheed Suhrawardy Medical College & Hospital, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/bjo.v30i2.80465

Keywords:

Antibacterial susceptibility, Bacteriological study,Ludwig’s angina,Microbial Pattern

Abstract

Background: Ludwig’s angina is a form of severe diffuse cellulitis that presents as acute onset and spreads rapidly, bilaterally affecting the submandibular, sublingual and submental spaces. Isolation of bacteria responsible for Ludwig’s angina and their antibiotic susceptibility is crucial as mixed infections are common.

Objectives: To find out the microbes responsible for developing Ludwig’s angina and their antibiotic susceptibility.

Methods: This cross-sectional study was conducted at Department of Otolaryngology and Head-Neck Surgery, Dhaka Medical College& Hospital, Dhaka, Bangladesh, from January 2018 to June 2019. Total 100 patients of Ludwig’s angina were enrolled. Surgical drainage followed by pus culture sensitivity was done to determine microbes responsible for Ludwig’s angina and analyzed the coverage rate of different antimicrobial agents.

Results: Mean (±SD) age of the study patients was 36.83±13.7 years and majority (45%) were in 3rd decade of life with a male predominance. Dental infection was the commonest source of infection and diabetes mellitus was the major (54.0%) predisposing factor. Isolated common organisms were Streptococcus viridians (30.6%), staphylococcus aureus (25.2%), E.coli (17.1%), Pseudomonas (11.7%), Klebsiella (9.9%) and Acinetobacter (5.4%). But no organism was found in 12 cases. Maximum patients (64%) were sensitized by Ceftriaxone, Gentamycin (55%) and Ciprofloxacin (46%). However, 11 study patients developed complications. Conclusion: Ludwig’s angina is common in middle aged male. Dental infection is the commonest source of infection and diabetes mellitus is an important risk factor. Streptococcus Viridans, Staphylococcus aureus, E.coli, Pseudomonas were the common causative organism. Most effective antibiotic were Ceftriaxone, Gentamicin and Ciprofloxacin.

Bangladesh J Otorhinolaryngology 2024; 30 (2): 48-57

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Published

2025-04-09

How to Cite

Islam, M., Rumi, S. N. F., Islam, M. N., Gangguly, D., Reza, I. H., & Parvez, S. R. (2025). Microbial Pattern and Antimicrobial Susceptibility of Ludwig’s : Study in a Tertiary Level Hospital in Bangladesh. Bangladesh Journal of Otorhinolaryngology, 30(2), 48–57. https://doi.org/10.3329/bjo.v30i2.80465

Issue

Vol. 30 No. 2 (2024)

Section

Original Articles

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