Effect of Intravenous Dexamethasone on Propofol Injection Pain: A Randomized Placebo Controlled Study

Authors

  • Muhammad Sazzad Hossain Associate Professor and HOD, Department of Anesthesiolgy, National Institute of ENT, Tejgaon, Dhaka
  • Md Afzalur Rahman Junior Consultant, Department of Anesthesiology, National Institute of ENT, Tejgaon, Dhaka
  • Mamunur Rashid Junior Consultant, Department of Anesthesiology, National Institute of ENT, Tejgaon, Dhaka
  • Monirul Islam Junior Consultant, Department of Anesthesiology, Shaheed Suhrawardy Medical College Hospital, Dhaka.
  • Anisur Rahman Babu Medical officer, Department of Anesthesiology, National Institute of ENT, Tejgaon, Dhaka
  • Mohammad Iftakhairul Hasan Medical Officer, Department of Anesthesia, Analgesia, Palliative and Intensive Care Medicine, Dhaka Medical College Hospital
  • Md Sirajul Islam Mahfuz Professor of ENT, National Institute of ENT, Tejgaon, Dhaka.

DOI:

https://doi.org/10.3329/bjo.v25i1.45192

Keywords:

Dexamethasone, propofol, general anesthesia, pain on propofol injection (POPI).

Abstract

Background and aim of study: Pain on propofol injection (POPI) is a common problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. This study was conducted to compare the efficacy of dexamethasone in attenuation of pain following intravenous injection of propofol.

Materials and methods: A total of 80 adult patients were scheduled in this study with either sex, ASA (American Society of Anesthesiologists) grade I and II, for routine elective surgical procedure under general anesthesia. The patients enrolled were divided randomly into two groups of 40 patients each. Group I received 0.15 mg/kg of intravenous dexamethasone in 5 ml normal saline and Group II (placebo group) received 5 ml of 0.9% intravenous normal saline, following exsanguination and occlusion of the vein of the arm. This was followed by 0.5 mg/kg of propofol intravenously.The patients were asked to report their pain during injection of propofol according to the McCririck and Hunter scale.

Results: The incidence of pain experienced in dexamethasone group was 45% patients and in saline group was 70% patients (p<0.05). The severity of POPI was also lower in dexamethasone group than the saline group (p<0.05). The incidence of mild and moderate pain in dexamethasone groups versus saline group was 30% versus 45% and 15% versus 25% respectively p<0.05. There was no severe pain recorded in any groups.

Conclusion: Pretreatment with intravenous dexamethasone (0.15 mg/kg) before injection of propofol is effective and safe in reducing the incidence and severity of pain on propofol injection (POPI).

Bangladesh J Otorhinolaryngol; April 2019; 25(1): 28-33

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Published

2020-01-28

How to Cite

Hossain, M. S., Rahman, M. A., Rashid, M., Islam, M., Babu, A. R., Hasan, M. I., & Mahfuz, M. S. I. (2020). Effect of Intravenous Dexamethasone on Propofol Injection Pain: A Randomized Placebo Controlled Study. Bangladesh Journal of Otorhinolaryngology, 25(1), 28–33. https://doi.org/10.3329/bjo.v25i1.45192

Issue

Vol. 25 No. 1 (2019)

Section

Original Articles

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