Utilization of Brain Tissue as A Viable Postmortem Toxicological Specimen: A Review on Collection and Preservationof Samplefor Toxicological Analysis and Its Advantage Over Other Specimens

Authors

  • Abu Sadat Mohammad Nurunabi Assistant Professor, Department of Anatomy, OSD, Directorate General of Health Services (DGHS), Dhaka, Bangladesh
  • Miliva Mozaffor Assistant Professor and Laboratory Consultant, Department of Biochemistry, Medical College for Women & Hospital, Uttara, Dhaka, Bangladesh
  • Mohammad Tipu Sultan Medical Officer, Department of Forensic Medicine & Toxicology, Dhaka Medical College, Dhaka, Bangladesh
  • Md Mozaharul Islam Assistant Professor, Department of Forensic Medicine & Toxicology, Shaheed Syed Nazrul Islam Medical College, Kishoreganj, Bangladesh
  • Kaisar Haroon Assistant Professor, Department of Clinical Neurosurgery, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjns.v11i2.61455

Keywords:

Postmortem Examination, Autopsy, Toxicological Analysis, Brain tissue, Blood, Urine

Abstract

Collection of proper autopsy specimen and preservation are essential stepsfor the toxicological analysis in Forensic Medicine. Faulty collection and preservation of the specimens/samples can greatly alter or negate forensic chemical or toxicologicalexamination. In forensic toxicology practicein Bangladesh, postmortem specimen that is subjected to toxicological examinations generally focusing on mainly blood and sometimes urine or other fuds from different body cavities. Analysis of blood from different anatomical sites and tissue samples and urine may assist in the interpretation of the postmortem results. However, in many postmortem cases, there is little or no blood for quantitative drug analysis, or there might be such traumatic injury which led to significant blood loss or there is possibility of contamination form contents of the ruptured stomach. Besides, analysis of urine reveals negative result, if death occurs closely the time of intoxication. Given the circumstances, brain tissue may be a valuable specimen in postmortem toxicological analysis. The position of the brain in the body secures a tremendous protection and isolation which can eliminates or at least attenuates many of the interpretive challenges with postmortem blood, urine or other fluid specimens.This review paper is an update on the standard methods of brain tissue specimen collection and preservationprocedures for toxicological analysis and its value as well as advantages over other specimens, which might be of possible interest for forensic professionals in the country.

Bang. J Neurosurgery 2022; 11(2): 114-117

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Published

2022-09-07

How to Cite

Nurunabi, A. S. M. ., Mozaffor, M., Sultan, M. T. ., Islam, M. M. ., & Haroon, K. . (2022). Utilization of Brain Tissue as A Viable Postmortem Toxicological Specimen: A Review on Collection and Preservationof Samplefor Toxicological Analysis and Its Advantage Over Other Specimens. Bangladesh Journal of Neurosurgery, 11(2), 114–117. https://doi.org/10.3329/bjns.v11i2.61455

Issue

Section

Review Article