External Ventricular Drainage Reduces Mortality in Spontaneous Intraventricular Hemorrhage of Brain: A Comparative Study

Authors

  • SM Noman Khaled Chowdhury Professor & Head, Department of Neurosurgery, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Mohammad Humayun Rashid Chief Resident, Department of Neurosurgery, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Mohammad Nazrul Hossain Associate Professor & Head, Department of Neurosurgery, Ibrahim Cardiac Hospital & Research Institute, Bangladesh
  • Syeda Asfiya Ara Assistant Professor, Department of Pathology, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Md Sharif Bhuiyan Resident, Department of Neurosurgery, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Tapas Sarker Chief Resident, Department of Neurosurgery, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Kamalesh Saha Registrar, Department of Neurosurgery, Khulna Medical College Hospital, Khulna, Bangladesh
  • Sirajul Munir Ohi Chief Resident, Department of Neurosurgery, Chittagong Medical College Hospital, Chattogram, Bangladesh

DOI:

https://doi.org/10.3329/bjns.v11i1.57986

Keywords:

Intraventricular Hemorrhage, External Ventricular Drainage, Acute Hydrocephalus, Spontaneous IVH

Abstract

Introduction: External ventricular drain (EVD) usage in patients with intraventricular hemorrhage (IVH) is variable in current practice and clinical trials, and its impact on outcome remains controversial. Aim of this study was to see the outcome of EVD in management of spontaneous IVH of brain assessing by Glasgow outcome scale (GOS) and modified Rankin scale (mRS) score compared with conservative management.

Materials and Methods: Between July 2018 and June 2019, a consecutive 125 admitted patients with spontaneous IVH were enrolled in this quasi-experimental study. Among them 56 patient’s relative agreed to surgery who were accepted as case group and had EVDs. Remaining 69 patient’s relative declined authorization for surgery and were accepted as control group and underwent conservative management. Baseline demographics, clinical presentation, and hospital course, Glasgow coma scale score (GCS) for level of consciousness and modified Graeb score (mGS) for severity of ventricular haemorrhage were recorded at baseline and postoperatively. Admission Computed tomography (CT) scans performed within 24 hours of admission were reviewed for IVH type and hydrocephalus. Patients were followed up for 3 months post operatively and assessed using the GOS score and mRS score.

Results: Both the groups were similar at baseline in terms of age (mean±SD: 59±14 vs 60±14, p = 0.645), sex and comorbidity distributions. However, patients who received EVDs had lower mean GCS score (p=<0.001) and higher mean mGS score (p= 0.015) than those who did not receive an EVD. Incidence of hydrocephalus was similar in both groups (57.4% vs 46.7%, p = 0.268). Among the 77 survivors at 3 months, there were 23.1% (6/21) patients scored mRSd”2 in case group, while 38.2% (13/34) in control group (P=0.211). After binary logistic regression analysis, EVD placement was independently associated with reduction of 90 days mortality than conservative management (OR: 3.982; 95% CI: 1.3-12.19) but no effect on morbidity and functional dependence. Other independent predictors for mortality were higher age (p=0.002), lower GCS at admission (p=<0.001) and presence of hydrocephalus (p= <0.001) on CT scan.

Conclusion:These results suggest that EVD placement may be beneficial for patients with IVH, who have particularly poor prognosis at admission, but our results must be validated in future randomized clinical trial with larger cohorts and longer follow-up periods that are sufficiently powered to control for the heterogeneity of the study population and managements.

Bang. J Neurosurgery 2021; 11(1): 3-12

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Published

2022-02-22

How to Cite

Chowdhury, S. N. K. ., Rashid, M. H. ., Hossain, M. N. ., Ara, S. A. ., Bhuiyan, M. S. ., Sarker, T. ., Saha, K. ., & Ohi, S. M. . (2022). External Ventricular Drainage Reduces Mortality in Spontaneous Intraventricular Hemorrhage of Brain: A Comparative Study. Bangladesh Journal of Neurosurgery, 11(1), 3–12. https://doi.org/10.3329/bjns.v11i1.57986

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Original Articles