Status of ToRCH positivity among the children presented with congenital Hydrocephalus

  • Sudipta Kumer Mukherjee Assistant Professor, Department of Pediatric Neurosurgery, National Institute of Neurosciences & Hospital, Sher-E-Bangla Nagar, Dhaka-1207
  • DM Arman Assistant Professor, Department of Clinical Neurosurgery, National Institute of Neurosciences & Hospital, Sher- E-Bangla Nagar, Dhaka-1207
  • Holly A Roy Academic Clinical Fellow in Neurosurgery Department, Derriford Hospital, Plymouth, PL6 8DH (UK)
  • Rafiul Karim Khan Assistant Professor, Department of Neurosurgery, Shaheed Suhrawardy Medical College Hospital
  • Samantha Afreen Major, Classified Specialist, Neurosurgery, CMH
  • Muhammad Arif Hossain Medical Officer, Department of Pediatric Neurosurgery, National Institute of Neurosciences & Hospital, Sher-E-Bangla Nagar, Dhaka-1207
  • - Md Ziauddin Assistant Registrar, Department of Pediatric Neurosurgery, National Institute of Neurosciences & Hospital, Sher- E-Bangla Nagar, Dhaka-1207
  • Sk Md Ekramullah Professor & Head, Associate Professor, Department of Pediatric Neurosurgery, National Institute of Neurosciences & Hospital, Sher-E-Bangla Nagar, Dhaka-1207
  • Md Moshiur Rahman Medical Officer, Department of Pediatric Neurosurgery, National Institute of Neurosciences & Hospital, Sher-E-Bangla Nagar, Dhaka-1207
  • Md Abdullah Yusuf Assistant Professor, Department of Microbiology, National Institute of Neurosciences & Hospital, Sher-EBangla Nagar, Dhaka-1207
  • Md Joynul Islam Associate Professor, Department of Clinical Neurosurgery, National Institute of Neurosciences & Hospital, Sher-E-Bangla Nagar, Dhaka-1207
Keywords: Congenital Infection, ToRCH, Hydrocephalus, Prevention, CMV, Toxoplasma

Abstract

Introduction: ToRCH is an acronym for four congenital infections that are sometimes difficult to distinguish: Toxoplasmosis, Rubella, Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV). This group of organisms produces serious Central Nervous System (CNS) and other infections, which are potentially preventable and treatable.

Methods: Neonates and infants with hydrocephalus (N = 65) identified via the outpatient department of the National Institute of Neurosciences and Hospital (NINS&H), were prospectively screened for ToRCH antibodies. Hydrocephalus secondary to Tumor or Trauma was excluded from this study.

Results: Evidence of 75.38 % (p = <0.05) patient was positive for TORCH antibodies. Toxoplasma Gondi (T. Gondii) IgG 18.5 % ( p= <0.05 ), CMV IgM 9.2 % (p = <0.05), CMV Ig G47.7% ( p = <0.5), Rubella, and HSV 1 & 2 antibodies were also identified.

Conclusion: The vast majority of cases of neonatal hydrocephalus at one institution was post-infectious in etiology and related to ToRCH infections. Many of these cases could be prevented with improved screening and treatment. While study of a single institution may not be the representative of the entire population, further study and implementation of a standardized screening protocol would likely benefit this population.

Bang. J Neurosurgery 2020; 9(2): 121-125

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Abstract
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Published
2020-01-14
How to Cite
Mukherjee, S., Arman, D., Roy, H. A., Khan, R. K., Afreen, S., Hossain, M. A., Md Ziauddin, -, Ekramullah, S. M., Rahman, M. M., Yusuf, M. A., & Islam, M. J. (2020). Status of ToRCH positivity among the children presented with congenital Hydrocephalus. Bangladesh Journal of Neurosurgery, 9(2), 121-125. https://doi.org/10.3329/bjns.v9i2.44886
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Original Articles