Association Between Wilson Disease and Parental Consanguinity in Bangladesh: A Meta-Analysis
Keywords:
Wilson disease; Bangladesh; consanguineous marriages; prevalenceAbstract
Objective This study aims to compare the prevalence of Wilson’s disease (WD) among individuals born to consanguineous marriages versus those born to non-consanguineous unions in Bangladesh. Materials and methods Several databases, including Web of Science, PubMed, Scopus, and Google Scholar and Bangla JOL were searched using relevant keywords. Eligible studies were those conducted in Bangladesh that reported either the number or percentage of parental consanguinity among patients with WD. Pooled prevalence and 95% confidence intervals (CIs) were calculated. Publication bias was assessed and sensitivity analysis was conducted. Results A total of 334 articles were initially identified, of which thirteen studies were ultimately included in the analysis. Findings demonstrated that 29.8% of WD patients were born to consanguineous parents (pooled event rate = 0.298, 95% CI = 0.24–0.35; I² = 48%), while 70.2% were born to non-consanguineous parents (pooled event rate = 0.702, 95% CI = 0.65–0.76). These findings suggest that most WD cases in Bangladesh occurred in nonconsanguineous families. Both Egger’s test (p=0.23) and Begg and Mazumdar’s test (p=0.12) suggested the absence of publication bias. Conclusion The results show that parental consanguinity does not significantly increase the risk of WD in people from Bangladesh.
Bangladesh Journal of Medical Science Vol. 25 No. 03 July’26 Page: 856-864
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Copyright (c) 2026 Md Mojahidur Hasan, Sehreen Tory, Hamdi Gokahmetoglu, Yusuf Tutar
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