Chemotherapy-Induced ECG Changes in HCC Patients

Authors

  • Saule Kubekova PhD, Astana Medical University, Astana, Kazakhstan
  • Yelena Rib PhD, Astana Medical University, Astana, Kazakhstan
  • Natalya Zagorulya MD, Astana Medical University, Astana, Kazakhstan
  • Niyaz Malayev MD, National Scientific Medical Center, Astana, Kazakhstan
  • Damir Biktashev PhD, Astana Medical University, Astana, Kazakhstan
  • Gaukhar Kuanyshbayeva PhD, Astana Medical University, Astana, Kazakhstan. gaukhar
  • Saltabayeva Ulbolssyn PhD, Astana Medical University, Astana, Kazakhstan
  • Akbayan Markabayeva PhD, Astana Medical University, Astana, Kazakhstan
  • Dinara Bayanova Astana Medical University, Astana, Kazakhstan
  • Ainur Donayeva Department of Emergency Medical Care, West Kazakhstan Marat Ospanov Medical University, Aklobe, Kazakhstan

DOI:

https://doi.org/10.3329/bjms.v24i4.84690

Keywords:

Chemotherapy, ECG Changes

Abstract

According to Globocan, in 2022, the highest incidence of hepatocellular carcinoma (HCC) was observed in Asia, which accounted for 75% of the global burden of liver cancer 1. In the Republic of Kazakhstan in 2022, the incidence of liver cancer was 5.1 per 100,000 population, with a mortality rate of 2.9, respectively. For the period 2014-2022, HCC had the lowest five-year survival rate among all malignant neoplasms in Kazakhstan2,3. The treatment of HCC across various stages involves a range of clinical strategies4. Sorafenib is currently the primary drug in the treatment of HCC 4,5 and doxorubicin is used in transarterial hepatic artery chemoembolization (TACE)8. However, their use results in cardiotoxicity leading to cancer therapeutics-related cardiac dysfunction (CTRCD)9. CRTCD manifests as cardiovascular disease symptoms in patients with HCC, reflecting irreversible structural changes in the myocardium10.

BJMS, Vol. 24 No. 04 October’25 Page : 1189-1196

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Published

2025-11-02

How to Cite

Kubekova, S., Rib, Y., Zagorulya, N., Malayev, N., Biktashev, D., Kuanyshbayeva, G., … Donayeva, A. (2025). Chemotherapy-Induced ECG Changes in HCC Patients. Bangladesh Journal of Medical Science, 24(4), 1189–1196. https://doi.org/10.3329/bjms.v24i4.84690

Issue

Vol. 24 No. 4 (2025)

Section

Original Articles

License

Copyright (c) 2025 Saule Kubekova, Yelena Rib, Natalya Zagorulya, Niyaz Malayev, Damir Biktashev, Gaukhar Kuanyshbayeva, Saltabayeva Ulbolssyn, Akbayan Markabayeva, Dinara Bayanova, Ainur Donayeva

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