Relationship between vitamin d status and cortisol in girls with primary dysmenorrhea

Authors

  • Dinara Kulzhanova Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Ainur Amanzholkyzy Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Ainur Donayeva Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Zhanslu Sarkulova Department of anesthesiology and reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Marat Sarkulov Departments of urology and andrology, including children’s, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Tokshilykova Ainur Department of anesthesiology and reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Yersulu Sagidanova Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Farida Balmaganbetova Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Samat Saparbayev Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Akzhunis Mannapova Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Natalya Zagorulya Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Saule Kubekova Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  • Assel Baubekova Department of Obstetrics and Gynecology, Astana Medical University, Astana, Kazakhstan

Keywords:

Primary dysmenorrhea; adolescent girls; vitamin D; cortisol

Abstract

Background & Aims Many adolescent girls and young women experience painful periods, medically known as primary dysmenorrhea (PD). Vitamin D deficiency and high cortisol levels seem to be connected and may even worsen the symptoms of PD. The aim of this research was to determine possible relationship between vitamin D and salivary cortisol levels in adolescent girls with PD. Methodology A total of 191 adolescent girls with PD aged 13-16 years were examined. All participants were randomly divided into two groups: the main group (n =96), which took vitamin D 4000 IU per day for three months and the control group (n =95), which took placebo. Further laboratory tests were carried out to determine the level of 25(OH) vitamin D in the blood serum and 4 samples of saliva to evaluate cortisol levels during the day before and after the intervention. Results & Conclusion After the intervention in the main group, an average negative relationship was revealed between the content of 25(OH) vitamin D in the blood with morning (r=- 0.4, p=0.001) and daytime (r=-0.25, p=0.041) levels of cortisol in the saliva of adolescent girls with PD, while no significant relationships were identified in the control group. We found that higher vitamin D levels were linked to lower cortisol levels in their saliva, especially in the mornings. This suggests a potential benefit of vitamin D in reducing stress hormones in these girls.

Bangladesh Journal of Medical Science Vol. 24 No. 02 April’25 Page : 496-504                 

Abstract
666
PDF
794

Downloads

Published

2025-05-17

How to Cite

Kulzhanova, D., Amanzholkyzy, A., Donayeva, A., Sarkulova, Z., Sarkulov, M., Ainur, T., Sagidanova, Y., Balmaganbetova, F., Saparbayev, S., Mannapova, A., Zagorulya, N., Kubekova, S., & Baubekova, A. (2025). Relationship between vitamin d status and cortisol in girls with primary dysmenorrhea. Bangladesh Journal of Medical Science, 24(2), 496-504. https://doi.org/10.3329/bjms.v24i2.81716

Issue

Vol. 24 No. 2 (2025)

Section

Original Articles

License

Copyright (c) 2025 Dinara Kulzhanova, Ainur Amanzholkyzy, Ainur Donayeva, Zhanslu Sarkulova, Marat Sarkulov, Tokshilykova Ainur, Yersulu Sagidanova, Farida Balmaganbetova, Samat Saparbayev, Akzhunis Mannapova, Natalya Zagorulya, Saule Kubekova, Assel Baubekova

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.

How to Cite

Kulzhanova, D., Amanzholkyzy, A., Donayeva, A., Sarkulova, Z., Sarkulov, M., Ainur, T., Sagidanova, Y., Balmaganbetova, F., Saparbayev, S., Mannapova, A., Zagorulya, N., Kubekova, S., & Baubekova, A. (2025). Relationship between vitamin d status and cortisol in girls with primary dysmenorrhea. Bangladesh Journal of Medical Science, 24(2), 496-504. https://doi.org/10.3329/bjms.v24i2.81716