Systemic mastocytosis associated with acute myeloid leukaemia

Authors

  • Mohd Nasiruddin Dhamirah Nazihah Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Wan Ab Rahman Wan Suriana School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Hussain Faezahtul Arbaeyah Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Husin Azlan Department of Medicine, School of Medical Science, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan
  • Saidin Nur Ilyia Syazwani Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Hassan Mohd Nazri Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Zulkafli Zefarina Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Mohamed Yusof Shafini Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Iberahim Salfarina Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia
  • Mohd Noor Noor Haslina Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Hospital Universiti Sains Malaysia

DOI:

https://doi.org/10.3329/bjms.v22i4.67129

Keywords:

systemic mastocytosis; acute myeloid leukaemia; mastocytosis; haematological neoplasm

Abstract

Bacground: The pathogenesis of systemic mastocytosis with associated haematological neoplasm (SMAHN) is not well understood. Both diagnoses heavily rely on morphological evaluation because SM is rarely suspected in clinical practise.

Objective: This case highlighted a possible delay in diagnosis due to underlying conditions or diseases.

Case Report: We present a case of a patient with acute myeloid leukaemia (AML), acute myelomonocytic subtype, and concurrent mastocytosis according to World Health Organization (WHO) classification. Due to an extensive accumulation of AML blast cells that obscured the mast cell infiltrates, mastocytosis was not evident at the first diagnosis.

Discussion and conclusion: The diagnosis, in this case, was established only in the third bone marrow biopsy after chemotherapy. A high index of suspicion with morphological and immunohistochemical evaluations for neoplastic mast cell populations should be considered. The optimal treatment approach should be chosen based on these two disease entities.

Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 937-941

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Published

2023-09-07

How to Cite

Nazihah, M. N. D. ., Suriana, W. A. R. W. ., Arbaeyah, H. F. ., Azlan, H. ., Syazwani, S. N. I. ., Nazri, H. M. ., Zefarina, Z. ., Shafini, M. Y. ., Salfarina, I. ., & Haslina, M. N. N. . (2023). Systemic mastocytosis associated with acute myeloid leukaemia. Bangladesh Journal of Medical Science, 22(4), 937–941. https://doi.org/10.3329/bjms.v22i4.67129

Issue

Section

Case Reports