Comparative assessment of the clinical efficacy of various amlodipine isomers in 1st and 2nd degree arterial hypertension patients

  • Dmitriy Ermakov Department of Pharmacy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
  • Olga Pashanova Department of Economics and Organization of Pharmacy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
Keywords: arterial hypertension; R-amlodipine; S-amlodipine; stereoselectivity; the structure and functional heart condition

Abstract

Objective: The paper presents the results of clinical trials of medications based on S-amlodipine and S/R-amlodipine.

Materials and methods: A total of 140 patients diagnosed with arterial hypertension of I and II degree were included into study, in particular, 70 patients with 1st degree and another 70 patients with 2nd degree hypertensive disease. A group consisted of 80 male (57%) and 60 female patients (43%) aged from 45 to 73 years. The average age of the examined patients was 62.1±5.8 years. Duration of the disease was established between 1 and 22 years (12.5±1.2 years on average).

Results and discussion: The stereoselectivity mechanisms of the studied amlodipine enantiomers were found to initiate the activity of only one S-amlodipine isomer. Applying S-amlodipine in treatment was proved to improve significantly the clinical results, facilitate the course of hypertensive disease, and normalize the structure and functional heart condition. After 8 weeks of amlodipine-based treatment, the diastolic pressure in groups receiving S-amlodipine reduced by 20-25% and systolic pressure reduction was between 20% and 31%. Among patients taking the original amlodipine medication consisting of S and R enantiomers, the diastolic pressure decrease was between 19.4% and 24%, and the systolic pressure reduced from 16.7% to 27.37%.

Conclusions: By using S-amlodipine, the prescribed medication dosage can be reduced by 50%, which allows diminishing the drug load on the body and lessen the side effects.

Bangladesh Journal of Medical Science Vol.20(2) 2021 p.439-448

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Abstract
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Published
2021-02-01
How to Cite
Ermakov, D., & Pashanova, O. (2021). Comparative assessment of the clinical efficacy of various amlodipine isomers in 1st and 2nd degree arterial hypertension patients. Bangladesh Journal of Medical Science, 20(2), 439-448. https://doi.org/10.3329/bjms.v20i2.51562
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Original Articles