The lead content in biological media term infants with hypoxic-ischemic CNS
Introduction: The frequency of births of infants with perinatal pathology has increased inrecent years. The aim of this study is to determination of lead content in the biomedias ofnewborns with hypoxic-ischemic damage of the central nervous system (CNS).
Materials andMethods: We studied influence of the lead content in children, which were born with hypoxicischemiclesion CNS (HIL CNS). Determination of this microelement was carried out in theblood serum, erythrocytes and urine of 30 newborn infants which were suffered from asphyxiaafter birth. The comparison group consisted of 30 healthy full-term newborns.
Results: In thebiomedias of children with the HIL of the central nervous system, a toxic trace element of leadhas been identified which is poorly retained in the placenta, so the fetus is more vulnerable toits toxic effects in the prenatal period. In the article the features of the lead content in serum,erythrocytes and urine in term infants which were born with hypoxic-ischemic CNS lesions areinvestigated. This group of subjects had increased serum and erythrocyte concentration of lead.The high content of lead in the erythrocytes of children with hypoxia which is already at birthmay indicate a transplacental penetration of this toxic trace element and the possibility of itsnegative impact on the course of pregnancy.
Conclusions: The prognostic significance of thelead content was high. Thus, the informative index (Ī) for lead content in serum is 7.40, and theprognostic factor (PC) is + 15.1. As for the prognostic value of the lead content in erythrocytesand urine, very high predictor properties are established for them: Ī = 7.44; PC = + 7.0 and Ī =13.42; PC = + 16.1 respectively.
Bangladesh Journal of Medical Science Vol.20(2) 2021 p.330-333
Copyright (c) 2021 Svitlana Kasian, Andrij Loboda, Oleksandr Smiyan, Serhiy Popov, Viktoriya Petrashenko, Mykola Zahorodnii, Ihor Zaitsev, Olena Redko, Iryna Shkolna
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:
- Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.
Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.