Investigation of gene markers and pathways in macrophages responsible for the Th1/Th17 inflammatory condition of Periodontal infection that can be candidates in stem cell therapy of the disease.

Authors

  • Chikoo Cherian Chikoo Cherian, Department of Biosciences and Technology, Karunya Institute of Science and Technology, India
  • Jannet Vennila James Jannet Vennila James, Department of Biotechnology, Karunya Institute of Technology and Sceinces, India

DOI:

https://doi.org/10.3329/bjms.v19i4.46611

Keywords:

Periodontitis; Treg; stem cells; molecular markers; pathways; macrophages

Abstract

Periodontitis is defined as a chronic gum disease with characteristic inflammation attributed byTh1/Th17 showing excessive immune responses and Tregs dysregulation occurring in the macrophages. Several genes and associated pathways have been identified which influence this condition. By deploying bioinformatics approaches and tools, the authors of this paper validated the presence of the responsible genes and identified its pathways. The current study focuses on using these genes as molecular markers and inhibiting their pathways in addition to conditioning the conversion of Th17 cells into Treg cells by introducing stem cell therapy. This study specifically used Wharton jelly or Umbilical cord stem cells therapy in the control and treatment of Periodontitis.

Bangladesh Journal of Medical Science Vol.19(4) 2020 p.594-597

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Published

2020-04-12

How to Cite

Cherian, C., & James, J. V. (2020). Investigation of gene markers and pathways in macrophages responsible for the Th1/Th17 inflammatory condition of Periodontal infection that can be candidates in stem cell therapy of the disease. Bangladesh Journal of Medical Science, 19(4), 594–597. https://doi.org/10.3329/bjms.v19i4.46611

Issue

Section

Review Article