Effects on thrombocytic hemostasis of a new derivate indolinone

  • VV Bykov Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • V Yu Serebrov Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • VV Udut Tomsk National Research Medical Center of the Russian Academy of Sciences, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, and National Research Tomsk State University, Tomsk, Russia
  • EV Udut Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • VP Fisenko First Moscow State Medical University of the Ministry of Health, Moscow, Russia
Keywords: antiplatelet, indolinone derivative, acetylsalicylic acid, dipyridamole, platelet aggregation

Abstract

Objective. Specific activity of an antiplatelet drug of indolinone series (codenamed DI) was studied in vitro in a model of ADP-induced platelet aggregation in vitro and in vivo in a model of streptozotocininduced diabetes mellitus in rats.

Material and Methods. Acetylsalicylic acid and dipyridamole were used as reference drugs. In vitro tests have demonstrated that DI exhibits antiplatelet activity in a wide range of concentrations (0,75×10-6 – 1.5×10-5 М, р<0,05), being comparable to acetylsalicylic acid and dipyridamole. In vivo tests have demonstrated dose-dependent antiplatelet activity of DI in doses of 2,5 – 20 mg/kg (21-14 %).

Results and Discussion.Increasing the dose of DI above 10 mg/kg doesn’t increase its antiplatelet activity. After multiple oral administration to rats with streptozotocin-induced diabetes mellitus in 10 mg/kg dose, DI has exhibited antiplatelet activity, reducing the platelet aggregation rate to that of the control group (р<0,05).

Conclusion. Thus, DI isapromisingcompound for furtherdevelopmentof an antiplatelet drug with new mechanism of action

Bangladesh Journal of Medical Science Vol.18(3) 2019 p.574-576

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Abstract
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Published
2019-05-30
How to Cite
Bykov, V., Serebrov, V., Udut, V., Udut, E., & Fisenko, V. (2019). Effects on thrombocytic hemostasis of a new derivate indolinone. Bangladesh Journal of Medical Science, 18(3), 574-576. https://doi.org/10.3329/bjms.v18i3.41628
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Original Articles