Immune profiling of saliva in patients with and without dental caries
Background: Dental caries is characterized by demineralization of inorganic portion of tooth and destruction of organic substances of tooth, which often leads to cavitation. The immune mechanisms play an important role in the pathogenesis of dental caries.This study was designed to determine the levels of salivary IgA, TGF-β and IL-17 in patients with dental caries.
Methodology: This was a comparative study of 87 individuals (29 healthy controls and 58 patients with dental caries) recruited from the Punjab Dental Hospital, Lahore. Group I included patients with dental caries up to 5 DMFT score (Decayed Missing Filled Teeth), group II had patients with 6 or more DMFT score and group III consisted of healthy individuals without dental caries. Commercially available ELISA kits were used for the detection of salivary IgA, TGF β and IL-17.
Results: Highest mean ± SD level of IL-17(2.99±1.11ng/L)and TGFβ (127.8 ±74.0ng/L) were detected in group III. While highest mean ± SD level of salivary IgA (μg/ mL) was detected in the group I (34.64±6.37μg/mL)
Conclusion: Level of salivary IgA was increased in patients of dental caries while levels of IL-17and TGFβ were decreased in patients of dental caries as compared to healthy individuals.
Bangladesh Journal of Medical Science Vol.18(3) 2019 p.536-539
Copyright (c) 2019 Nadeem Afzal
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:
- Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.
Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.