Correlation of VEGF expression with prognostic factors of breast carcinoma

  • Jhuma Nandi Junior Resident, Department Of Pathology, NRS Medical College, Kolkata
  • Moumita Maiti Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata, India
  • Neepamanjari Barman Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata
  • Moumita Paul Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata
  • Sreepurna Medda Demonstrator , Department Of Pathology, NRS Medical College, Kolkata
  • Sushil Ranjan Ghosal Professor and Head, Department Of Surgery, NRS Medical College, Kolkata
  • Ranu Sarkar Professor and Head, Department Of Pathology, NRS Medical College, Kolkata
Keywords: Correlation of VEGF, prognostic factors, breast carcinoma

Abstract

Background: Breast carcinoma is the most common malignant tumour and leading cause of cancer death among women worldwide. VEGF being a powerful mediator of angiogenesis, plays a major role in local growth as well as metastasis of many solid tumours including breast carcinoma.

Objective: This study aimed to evaluate the significance of VEGF expression in breast cancer and its correlation with prognostic parameters. Materials and methods: This study was conducted over a period of one year (February 2015 to January 2016). VEGF expression was evaluated in 57 histologically diagnosed cases of breast carcinoma with known ER and HER-2/neu status.

Result: Among 57 cases 52(91.2%) were positive for VEGF. Positive ER expression was seen in 39 cases which is 64.8% of total cases. 54% of the total cases were positive for HER-2/neu. VEGF expression was positively correlated (P value <0.05) with tumour grade, tumour size and negatively correlated with ER (p<0.005) and HER-2/neu (p<0.005). Significant correlation also found with tumour type (p<.005).

Conclusion: Considering the observations of the current study, it can be concluded that VEGF may play a crucial role in the pathogenesis of breast carcinoma and has a positive correlation with biologically aggressive tumour. So consideration of this biomarker (VEGF) is to be regarded as a prognostic parameter and critical evaluator of targeted chemotherapy

Bangladesh Journal of Medical Science Vol.18(3) 2019 p.513-518

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Abstract
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Published
2019-05-30
How to Cite
Nandi, J., Maiti, M., Barman, N., Paul, M., Medda, S., Ghosal, S., & Sarkar, R. (2019). Correlation of VEGF expression with prognostic factors of breast carcinoma. Bangladesh Journal of Medical Science, 18(3), 513-518. https://doi.org/10.3329/bjms.v18i3.41619
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Original Articles