The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats

  • Ulfah Dian Indrayani Department of Histology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
  • Hadi Sarosa Department of Physiology Faculty of Medicine Sultan Agung Islamic University, Semarang, Indonesia
  • Atina Hussaana Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
  • Bagas Widiyanto Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
Keywords: Sauropus androgynous extract; Moringaoleiefera extract; Combination extract; antianemia

Abstract

Background: Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The combination of the two extracts have been known to potentially have a synergistic effect on anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats.

Methods: Thirty female wistarstrain rats were randomly divided into 5 groups: normal, iron deficiency anemia, Sa, Mo and the combination of Sa and Mo. Beside the normal group, rats were fed Fe-deficient diet to induce iron-deficiency anemia. Level of hemoglobin, ferritin and plasma MDA were measured on day 8 (after induction of anemia) and day 29. Data were analyzed using One Way ANOVA followed by LSD post hoc test.

Result: The rats fed with Fe-deficient diet for 7 days shown significantly had a lower plasma Hb and ferritin levels and higher plasma MDA levels compared to the normal group (p <0.05) After the treatment, the rats given the extracts significantly had a higher mean of Hb and Ferritin and a lower mean of MDA level compared to anemic control. The mean Hb, ferritin and MDA level of the combination group were close to normal group.

Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.136-140

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Author Biographies

Ulfah Dian Indrayani, Department of Histology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Atina Hussaana, Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Bagas Widiyanto, Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Published
2018-12-30
How to Cite
Indrayani, U., Sarosa, H., Hussaana, A., & Widiyanto, B. (2018). The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats. Bangladesh Journal of Medical Science, 18(1), 136-140. https://doi.org/10.3329/bjms.v18i1.39564
Section
Original Articles