Effect of heavy metals on the readaptive processes in the urinary bladder

  • Anatolii Romaniuk Prof., Head of Pathology Department. Sumy State University, Department of Pathology
  • Vladyslav Sikora Sumy State University, Department of Pathology, Ukraine
  • Yulia Lуndіna Sumy State University, Department of Normal Anatomy, Ukraine
  • Mykola Lуndіn Sumy State University, Department of Pathology, Ukraine.
  • Natalia Hyriavenko Sumy State University, Department of Pathology, Ukraine
  • Volodymyr Sikora Sumy State University, Department of Surgery and Oncology, Ukraine
  • Ludmila Karpenko Sumy State University, Department of Pathology, Ukraine
  • Artem Piddubnyi Sumy State University, Department of Pathology, Ukraine
  • Maryna Miroshnichenko Sumy State University, Ukraine
Keywords: urinary bladder; heavy metals; readaptation, rats; vitamin E.

Abstract

Introduction: Heavy metals (HM) are dangerous elements due to their toxicity and prevalence play an important role in the environmental pollution and hazards to health risk. Impact of HM at high concentrations may lead to the failures of urinary bladder (UB) structure and functions. The aim of our study was to determine the readaptive changes in the UB of the rats and effectiveness of vitamin E using after the long-term intake of the HMS mixtures.

Materials and Methods: We used mature male laboratory rats which were divided into three series with special experimental conditions after the influence of HM. The detailed analysis of the UB state was performed by using morphometric, spectrophotometric, histological and electron microscopy methods.

Results: We had determined that the long-term intake of HM caused the significant increase of their accumulation in the tissue and morphometric changes of UB. Obtained results after the cancelation of the HM effect demonstrate smooth morphological restructuring of the UB wall with the reduction of difference of accumulation and morphometric indicators with control. The adjustment of vitamin E during there adaptation period showed better result recovery and optimization of all parameters, but they haven’t completely returned to normal state.

Conclusions: The influence of HMS mixture led to significant negative effect on the UB at all stages of research. However, under the conditions of readaptation the tendency towards a certain stabilization of all indicators was observed, but they didn’t completely pass to the end of the study. The vitamin E using has caused the acceleration and improved the development of readaptive change after HM exposure.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.100-106

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Author Biographies

Anatolii Romaniuk, Prof., Head of Pathology Department. Sumy State University, Department of Pathology

Department of Pathology

Vladyslav Sikora, Sumy State University, Department of Pathology, Ukraine

Department of Pathology

Yulia Lуndіna, Sumy State University, Department of Normal Anatomy, Ukraine

Department of Normal Anatomy

Natalia Hyriavenko, Sumy State University, Department of Pathology, Ukraine

Department of Pathology

Volodymyr Sikora, Sumy State University, Department of Surgery and Oncology, Ukraine

Department of Surgery and Oncology

Ludmila Karpenko, Sumy State University, Department of Pathology, Ukraine

Department of Pathology

Artem Piddubnyi, Sumy State University, Department of Pathology, Ukraine

Department of Pathology

Published
2018-12-30
How to Cite
Romaniuk, A., Sikora, V., LуndіnaY., LуndіnM., Hyriavenko, N., Sikora, V., Karpenko, L., Piddubnyi, A., & Miroshnichenko, M. (2018). Effect of heavy metals on the readaptive processes in the urinary bladder. Bangladesh Journal of Medical Science, 18(1), 100-106. https://doi.org/10.3329/bjms.v18i1.39558
Section
Original Articles