Potential Immuno-modulatory activity of Probiotics containing Lactobacillusacidophilus and Lacobacilluscasei to increase the ratio of IFN γ/IL-4 in patients with Allergic Rhinitis

  • Andriana Tjitria Widi Wardani Department of otorhinolaryngology-Head & Neck, Faculty of Medicine, Universitas Islam Sultan Agung
  • - Wiratno Department of Otorhinolaryngology-Head & Neck, Faculty of Medicine, Universitas Islam Sultan Agung
  • Dina Fatmawati Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung
Keywords: allergic rhinitis; Interferon gamma; interleukin-4; Probiotics

Abstract

Aims: This study aimed to determine the effect of probiotic combination on ratio of IFN-γ: IL-4 levels in patients with allergic rhinitis.

Materials and methods: Single blind, randomized controlled trial.This study included 40 patients with severe allergic rhinitis according to WHO criteria. This study used 2 treatment groups with probiotics and placebo control group. IFN γ and IL-4 levels were evaluated using ELISA method. Data were analyzed using paired T test with 95% confidence intervals

Results and Discussion: In the treatment group, the levels of IFN-γ increased significantly (p<0.05).In contrast, IL-4 levels decreased significantly(p<0.05). There was a significant difference between the IFN-γ ratio: IL-4 treatment and control group (p <0.05).

Conclusion: The administration of combination of probiotics can improve the levels of IFN-γ/ IL-4 in patients with moderate to severe allergic rhinitis.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.42-45

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Author Biographies

- Wiratno, Department of Otorhinolaryngology-Head & Neck, Faculty of Medicine, Universitas Islam Sultan Agung

Department of Otorhinolaryngology-Head & Neck

Dina Fatmawati, Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung

Department of Biology

Published
2018-12-30
How to Cite
Wardani, A. T., Wiratno, -, & Fatmawati, D. (2018). Potential Immuno-modulatory activity of Probiotics containing Lactobacillusacidophilus and Lacobacilluscasei to increase the ratio of IFN γ/IL-4 in patients with Allergic Rhinitis. Bangladesh Journal of Medical Science, 18(1), 42-45. https://doi.org/10.3329/bjms.v18i1.39545
Section
Original Articles