Study of Cucurbita extract effect on changes of AGEs, lipid and glycemic profile and CRP in type 1 diabetic rats
DOI:
https://doi.org/10.3329/bjms.v17i1.35286Keywords:
Plant extract, squash, glucose, rat, cholesterol, triglyceride, diabetesAbstract
Background: Clinically, diabetes is an important risk factor or a range of diseases including nephropathy,retinopathy, angiopathy and deficiency and it is increasing in prevalence according to some estimates. (Cucurbita pepo L.) from the cucurbitaceae family has a low calorie but high nutritional and medical value. The aim of this study was to observe the effect of cucurbita extract on serum factors of STZ induced diabetic rats including glucose level AGEs, lipid profile (cholesterol, HDL, LDL, and TG) and CRP.
Material and methods: Diabetes type1 was induced to Male albino- wistar rats by STZ at a dosage of 50 mg kg-1. 17 rat were divided into three groups randomly including diabetic treated with extract, diabetic control and normal group. Diabetic group were force fed orally by cucurbita extract. The animals were anesthetized with ether at the end of 30 days and the blood was collected by syringe from their hearts for estimation of plasma glucose, TG, HDL, LDL, total cholesterol, CRP and AGEs
Results: After measuring the serum factors and compares the result of the three groups to each other meaningful difference that shows the positive effect of cucurbita extract has been seen.
Conclusion: According to the results we suggest that squash extract could have positive effect on regulating some of blood elements like glucose which are under the bad effect of diabetes type1 in rats. But more investigations are needed in this field to demonstrate the real benefits of cucurbita in curing diabetes and its related signs.
Bangladesh Journal of Medical Science Vol.17(1) 2018 p.84-87
Downloads
29
24
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:
- Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.
Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.- Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.