Onosma bracteatum wall: A Potent analgesic agent

Authors

  • Hina Imran Senior Medical Officer, Pharmacology Section, Pharmaceutical Research Centre, PCSIR Labs Complex
  • Atiq ur Rahman Pharmacology Section, Pharmaceutical Research Centre, PCSIR Labs Complex, Karachi
  • Tehmina Sohail Pharmacology Section, Pharmaceutical Research Centre, PCSIR Labs Complex, Karachi
  • S Intasar H Taqvi Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi
  • Zahra Yaqeen Pharmacology Section, Pharmaceutical Research Centre, PCSIR Labs Complex, Karachi

DOI:

https://doi.org/10.3329/bjms.v17i1.35276

Keywords:

bracteatum, Tail flick test, Acetic acid induced writhing test, albino rats and mice

Abstract

Background: This study was aimed to find out the central and peripheral analgesic activity of hydro methanolic extract of aerial parts of Onosma bracteatum.

Material and methods: The central and peripheral analgesic activity is evaluated by tail flick test and acetic acid induced writhing test at the doses of 50, 100, 250 and 500mg/kg body weight respectively in animal models.

Results: The results obtained from Tail flick test revealed that O. bracteatum possesses potent analgesic effects by inducing significant increase in latency period in dose dependent manner at all doses at 1, 2 and 3 hours post feeding respectively. The maximum effect was observed at a dose of 500mg/kg i.e. 258.9% (p<0.05) at 3hrs post feeding. Diclofenac sodium (5mg/kg body weight) run as standard also increased the latency period continuously and highest activity was noted at 3hr i.e. 284.5% (p<0.05). Acetic acid induced writhing test also showed significant activity in a similar manner by O. bracteatum i.e 54% (p<0.05) at 500mg/kg while standard drug Diclofenic sodium (5mg/kg body weight) showed 45.9% (p<0.05) activity.

Conclusion: It is concluded that O. bracteatum possesses significant central and peripheral analgesic activity in animal model.

Bangladesh Journal of Medical Science Vol.17(1) 2018 p.36-41

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Published

2018-01-11

How to Cite

Imran, H., Rahman, A. ur, Sohail, T., Taqvi, S. I. H., & Yaqeen, Z. (2018). Onosma bracteatum wall: A Potent analgesic agent. Bangladesh Journal of Medical Science, 17(1), 36–41. https://doi.org/10.3329/bjms.v17i1.35276

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Section

Original Articles