Role of T Lymphocytes In Chronic Leukemia

Authors

  • MW Al Rabea College of Medicine, King Abdulaziz University, Jeddah
  • MA Al Nafea Dept of Radiology, CAMS, KSU, Riyadh
  • WG Tamimi Dept. of Biochemistry, Pathology Dept, KAMC, Riyadh
  • Faris Q Alenzi Dept. of Med Lab Sci., CAMS, Prince Sattam bin Abdulaziz University, Al-Kharj

DOI:

https://doi.org/10.3329/bjms.v16i2.31939

Abstract

Functional immune cells are required for the prevention or resolution ofimmune-mediated disease , in particular T cells, including helper (CD4+; Th) or cytotoxic (CD8+; Tc) T cells. Th cells differentiate into Th1 or Th2 type cells, through production of inflammatory (IL-2, IFN-a) or anti-inflammatory (IL-4, TGF-ß) cytokines, respectively. Th cells also can differentiate into a third type of Th cells termeds Th17 type cells that produces IL-17 thereby mimicing the effects of Th1 cells. Th type cells can also differentiate under certain conditions into a regulatory (T-reg) type cell capable of secreting immunosuppressive cytokines such as TGF-ß and IL-10. This mini-review discusses the importance of T cell plasticity in regulating the nature of the immune cell responses seen in inflammatory diseases or cancer.

Bangladesh Journal of Medical Science Vol.16(2) 2017 p.207-211

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Author Biography

MW Al Rabea, College of Medicine, King Abdulaziz University, Jeddah



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Published

2017-03-23

How to Cite

Rabea, M. A., Nafea, M. A., Tamimi, W., & Alenzi, F. Q. (2017). Role of T Lymphocytes In Chronic Leukemia. Bangladesh Journal of Medical Science, 16(2), 207–211. https://doi.org/10.3329/bjms.v16i2.31939

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Section

Review Article