Utility of Biomarkers in Sepsis: Mirror Reflection of Inner Truculent Devil

Authors

  • Sunil Kumar Kota Department of Endocrinology, Medwin Hospital, Hyderabad-500001, Andhra Pradesh
  • Lalit Kumar Meher Department of Medicine, MKCG Medical College, Berhampur, Orissa
  • Epari Sanjeeva Rao Department of Pathology, KIMS Research Foundation, Amalapuram, Andhra Pradesh
  • Sruti Jammula Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Ambapua, BERHAMPUR-760010, Orissa
  • Siva Krishna Kota Department of Anaesthesia, Central Security Hospital, Riyadh- 11481
  • Kirtikumar D Modi Department of Endocrinology, Medwin Hospital, Hyderabad-500001, Andhra Pradesh

DOI:

https://doi.org/10.3329/bjms.v12i1.13349

Keywords:

Sepsis, Inflammation, Biomarkers

Abstract

There is a plethora of biomarkers proposed and being researched in the field of sepsis. The complex pathophysiology of sepsis involves many mediators of inflammation pertaining to coagulation, complement, contact system activation, inflammation, apoptosis, etc. Markers related to those processes can gauge the degree of sepsis. Compared with localized pathology, the systemic nature and involvement of multiple organs in sepsis gives scope for numerous potential biomarkers. There is no 'gold standard' for the diagnosis of sepsis. Currently available/in-research biomarkers are compared for their efficacy with methods used to diagnose and monitor sepsis such as combination of clinical signs and available laboratory variables. An arbitrary classification of these biomarkers is made and the literature surrounding these markers and their efficacy in diagnosis of sepsis is reviewed.

DOI: http://dx.doi.org/10.3329/bjms.v12i1.13349

Bangladesh Journal of Medical Science Vol. 12 No. 01 January13 pp.17-29

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Published

2013-01-17

How to Cite

Kota, S. K., Meher, L. K., Rao, E. S., Jammula, S., Kota, S. K., & Modi, K. D. (2013). Utility of Biomarkers in Sepsis: Mirror Reflection of Inner Truculent Devil. Bangladesh Journal of Medical Science, 12(1), 17–29. https://doi.org/10.3329/bjms.v12i1.13349

Issue

Vol. 12 No. 1 (2013)

Section

Review Article

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