Hypoglycemic, Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan-Induced Diabetic Rats.

Authors

  • Chika Anna Onyeka Department of Anatomy. Madonna University, Elele. River State
  • Agnes Akudo Nwakanma Department of Anatomy, Anambra State University Uli-Anambra State
  • Adeola Airat Bakare Department of Anatomy College of Medicine of the University of Lagos, Idi-Araba, Lagos State
  • Ini Ibehe Okoko Department of Anatomy College of Medicine of the University of Lagos, Idi-Araba, Lagos State,
  • Uzozie Chikere Ofoego Department of Anatomy, Anambra State University, Uli-Anambra State
  • Catherine Chukumuaya Wali Department of Anatomy, College of Medicine of the University of Lagos, Idi-Araba, Lagos State
  • Favour Chinyere Abengowe Department of Anatomy, College of Medicine of the University of Lagos, Idi-Araba, Lagos State

DOI:

https://doi.org/10.3329/bjms.v12i3.12721

Keywords:

Chrysophyllum albidum, alloxan, diabetes mellitus, metformin, pancreas

Abstract

Objective: The study was aimed at investigating the hypoglycemic, antioxidant and Hepatoprotective effects of Chrysophyllum albidum in diabetes induced male Wistar rats.

Methods: Ethanol root bark extract was administered to thirty rats of six groups A, B, C, D, E and F of five rats each, weighing between 150-170g. Diabetes was induced in Groups B, C, D, E and F using a single intraperitoneal injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal control while Group B served as the diabetic control. Group C had metformin of 500mg while Groups D, E and F received 50, 100 and 200mg/kg / bw/ day of the plant extract respectively through orogastric intubation. All the animals were given normal rat chow and water freely. Blood glucose level was determined and the experiment lasted for 3 weeks. On day 21 after an overnight fast, animal were anaesthetized and blood samples were collected by cardiac puncture under inhaled chloroform for the determination of superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) assays. The liver function test, ALT, AST and ALP was determined.

Result: This showed that C. albidum and metformin significantly (p < 0.05) lowered the Fasting blood glucose (FBS), the activities of SOD and CAT was dose- dependently increase when compared to the diabetic  control and there was also a reduction of  MDA in the treated groups. There was decrease in the activity of ALT, AST and ALP, which was also dose-dependent.

Conclusion: The results showed that the plant has significant antidiabetic activity and could therefore be employed for the treatment of diabetes mellitus in which free radicals are implicated.

Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 298-304

DOI: http://dx.doi.org/10.3329/bjms.v12i3.12721

 

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Author Biography

Chika Anna Onyeka, Department of Anatomy. Madonna University, Elele. River State

Anatomy Department. Lecturer

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Published

2013-06-23

How to Cite

Onyeka, C. A., Nwakanma, A. A., Bakare, A. A., Okoko, I. I., Ofoego, U. C., Wali, C. C., & Abengowe, F. C. (2013). Hypoglycemic, Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan-Induced Diabetic Rats. Bangladesh Journal of Medical Science, 12(3), 298–304. https://doi.org/10.3329/bjms.v12i3.12721

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Original Articles