The Correlation Between Lipid Profile and Proteinuria In Adult Nephrotic Syndrome Patients in Bangladeshi Population

Abstract

The nephrotic syndrome is a constellation of abnormalities that includes massive proteinuria, hypoalbuminemia and edema. Dyslipidemia is an important secondary biochemical abnormalities in nephrotic syndrome due to proteinuria and hypoalbuminemia. Dyslipidemia in nephrotic syndrome involved in the cardiovascular risk and also accelerates the progression of glomerular dysfunction. This study was conducted to evaluate the relationship between dyslipidemia and proteinuria in adult nephrotic syndrome patients. A total of 50 (fifty) diagnosed adult nephrotic syndrome patients from the Dept of Nephrology, Dhaka Medical College, Dhaka with age range from 20-50 years of both sexes were enrolled as study subjects. To evaluate the correlation between serum TC, TAG, HDL-C and LDL-C with 24 hour urinary total protein. This case control study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka, during the period of July 2013 to June 2014. With baseline information, lipid profile and 24 hour urinary total protein of study subjects were estimated. Mean values of the variables were determined. Correlation between variables were determined by Pearson's correlation test by using SPSS for windows version 20.0. For all the statistical analysis p<0.05 was considered as significant. Mean(±SD) values of serum total cholesterol (Tchol), TAG, HDL-C and LDL-C in adult nephrotic syndrome patients were 288.23±35.67 mg/dl, 174.53±18.86 mg/dl, 23.71±4.58 mg/dl and 231.16±34.28 mg/dl respectively. Mean value of 24 hour urinary total protein in study subjects was 5.65±0.54 gm/d. Positive correlation was found between 24 hour urinary total protein and Tchol (r=0.476, p<0.05), TAG (r=0.354, p<0.05), LDL-C (r=0.444, p<0.05) and positive correlation was found between 24 hour urinary total protein and HDL-C (r=0.028 p>0.05). Dyslipidemia in adult nephrotic syndrome possesses a significant relationship with proteinuria which could predispose them to develop coronary artery disease.

Bangladesh J Med Biochem 2018; 11(2): 24-33