Ameliorative Effects of Aloe Vera Gel Extract on Circulatory and Tissue Lipid Profile Status in Streptozotocin-Induced Diabetic Rats

  • RN Ugbaja Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • DI Akinloye Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • AJ Akamo Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • EI Ugwor Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • OO IIesanmi Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • O Tytler Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • M Ogunbona Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
  • O Ademuyiwa Dept of Biochemistry, College of Biosciences, Federal University of Agriculture Abeokuta, Ogun State
Keywords: Diabetes, Aloe vera, streptozotocin, lipid profile, dyslipidemia

Abstract

Diabetes is characterized by hyperglycaemia with alterations of lipid parameters. The effects of Aloe vera (A.V) gel extract on lipid profiles of streptozotocin-induced diabetic rats were investigated. Seventy-two male albino rats were randomly divided into six groups of 12 rats each; control, diabetic control, 4 ml/kg and 8 ml/kg body weight (b.w.) A.V, 10 mg/kg b.w. glibenclimide and non-diabetic 8 ml/kg b.w. A.V groups. They were treated for 14 and 28 days. The plasma and HDL lipid profiles (triacylglycerols, cholesterol and phospholipids) of the diabetic rats were significantly (p<0.05) increased, while those of the VLDL+LDL, RBC, RBC membrane and organs were observed to be significantly (p<0.05) reduced, when compared to the control after 14 and 28 days of treatment. A.V gel extract significantly (p<0.05) ameliorated the disruptions observed in the lipid profiles of the diabetic and thus provide a scientific rationale for the use of Aloe vera as a therapeutic agent.

Bangladesh J Med Biochem 2016; 9(1): 11-26

Downloads

Download data is not yet available.
Abstract
550
PDF
611
Published
2018-03-27
How to Cite
Ugbaja, R., Akinloye, D., Akamo, A., Ugwor, E., IIesanmi, O., Tytler, O., Ogunbona, M., & Ademuyiwa, O. (2018). Ameliorative Effects of Aloe Vera Gel Extract on Circulatory and Tissue Lipid Profile Status in Streptozotocin-Induced Diabetic Rats. Bangladesh Journal of Medical Biochemistry, 9(1), 11-26. https://doi.org/10.3329/bjmb.v9i1.36150
Section
Original Articles