Evaluation of Adenosine Deaminase (ADA) Activity for Diagnosis of Tubercular Pleural Effusion

  • SK Bhoumik Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka
  • MM Rahman Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka
  • M Ibrahim Department of Clinical Biochemistry, Lab Medicine, Apollo Hospital, Dhaka
  • MM Hiron Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka
  • M Ahamad Department of Respiratory Medicine, Dhaka Medical College, Dhaka
Keywords: Adenosine deaminase (ADA), Tubercular Pleural Effusion (TPE), Extra Pulmonary Tuberculosis (EPTB)

Abstract

To find out a sensitive and specific marker for early diagnosis of tubercular pleural effusion, this cross sectional study was carried out in the of National Institute of Diseases of the Chest and Hospital (NIDCH), Dhaka. One hundred and three pleural effusion cases were enrolled in the study. Out of the 103 cases, 62 were tubercular pleural effusion cases and 49 were nontubercular cases. Among the nontubercular cases, 30 cases were due to malignancy, 8 were due to pneumonia and rest 3 cases were due to nephrotic syndrome, congestive cardiac failure and rheumatoid arthritis. Considering 40 U/L as a cut off value for ADA level, the test result was positive in 58 out of 62 patients of tuberculosis indicating sensitivity of the test as 94%; however, among 41 non-tuberculous patients, 5 presented ADA activity level more than 40U/L, which lowers the specificity of the test to 88%. ADA levels were significantly higher in tuberculous than in nontuberculous cases (p value <0.001). It may be concluded that ADA levels are significantly high in patients with tuberculous pleural effusion compared to that in non-tubercular group. Sensitivity (94%) and specificity (88%) of the test in tuberculous pleural effusions are very high, when cut off value set at 40U/L. The result indicated that the analysis of ADA levels in pleural effusion constitute a very useful marker for the diagnosis of tubercular pleural effusion (TPE) which, in addition, can be made quickly in a noninvasive way.

DOI: http://dx.doi.org/10.3329/bjmb.v6i2.17642

Bangladesh J Med Biochem 2013; 6(2): 40-48

Downloads

Download data is not yet available.
Abstract
618
PDF
1086
Published
2014-01-13
How to Cite
Bhoumik, S., Rahman, M., Ibrahim, M., Hiron, M., & Ahamad, M. (2014). Evaluation of Adenosine Deaminase (ADA) Activity for Diagnosis of Tubercular Pleural Effusion. Bangladesh Journal of Medical Biochemistry, 6(2), 40-48. https://doi.org/10.3329/bjmb.v6i2.17642
Section
Original Articles