Confocal Laser Endomicroscopy in Diagnostics of Complications of Gastroesophageal Reflux Disease in Children

  • Anton Andreevich Shavrov Department of Endoscopy, FSBI ?Scientific Center of Children?s Health,? RAMS, Moscow
  • Igor Vitalevich Kirgizov Department of Endoscopy, FSBI ?Scientific Center of Children?s Health,? RAMS, Moscow
  • Andrey Alexandrovich Shavrov Department of Endoscopy, FSBI ?Scientific Center of Children?s Health,? RAMS, Moscow
  • Anastasiya Yurevna Kharitonova Department of Endoscopy, FSBI ?Scientific Center of Children?s Health,? RAMS, Moscow
  • Alexander Gavrilovich Talalaev Pathological Laboratory, FSBI ?Scientific Center of Children?s Health? Moscow
  • Galina Vasilevna Volynets Department of Gastroenterology with a hepatological group, FSBI ?Scientific Center of Children?s Health? Moscow
  • Sergei Germanovich Khomeriki Pathological Laboratory, Central Institute of Gastroenterology, Moscow
Keywords: Confocal laser endomicroscopy, Gastroesophageal reflux disease, Polyps of cardioesophageal passage, Pediatrics, Barrett oesophagus, GERD, Children, pCLE

Abstract

Twenty-nine children with suspected gastroesophageal reflux disease (GERD) and 17 children as a reference group were enrolled in the study. A conventional white light endoscopy of the oesophagus was supplemented by a probe-based confocal laser endomicroscopy (pCLE) and followed by a biopsy for histological examination. A comparative analysis of endoscopic, endomicroscopic, and histological data were performed. The pCLE allows detecting oesophagitis with the sensitivity and specificity of 93% and 94%, respectively; gastric and intestinal metaplasia typical for Barrett oesophagus with 83% and 100%, respectively; and polyps of the cardioesophageal passage with the sensitivity of 89% in patients with long-term GERD. Thus, this method allows taking an optical biopsy of pathological changes of esophageal mucosa just during the standard endoscopic investigation.

DOI: http://dx.doi.org/10.11593/bje.2013.0102.0012

Bangladesh Journal of Endosurgery Vol.1(2) May 2013: 1-6

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Abstract
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Published
2013-07-29
How to Cite
Shavrov, A., Kirgizov, I., Shavrov, A., Kharitonova, A., Talalaev, A., Volynets, G., & Khomeriki, S. (2013). Confocal Laser Endomicroscopy in Diagnostics of Complications of Gastroesophageal Reflux Disease in Children. Bangladesh Journal of Endosurgery, 1(2), 1-6. Retrieved from https://www.banglajol.info/index.php/BJE/article/view/15930
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Original Articles