Investigation of ephedra altissima compounds: histological Insights and in silico targeting of dihydrofolate reductase in aspergillus flavus

Authors

  • Houas Yamina Laboratory of Ecology and Management of Natural Ecosystems, Faculty Snv-Stu, University of Tlemcen, Algeria
  • Hassani Faiçal Laboratory of Ecology and Management of Natural Ecosystems, Faculty Snv-Stu, University of Tlemcen, Algeria
  • Abdelli Imane Ecole Supérieure en Sciences Appliquées, ESSA-Tlemcen, BP 165 RP Bel Horizon, Tlemcen 13000, Algeria.
  • Ghalem Sarra Laboratory of Ecology and Management of Natural Ecosystems, Faculty Snv-Stu, University of Tlemcen, Algeria
  • Bekkal Bereksi Sohayb Laboratory of Ecology and Management of Natural Ecosystems, Faculty Snv-Stu, University of Tlemcen, Algeria

DOI:

https://doi.org/10.3329/bjb.v54i4.86576

Keywords:

Ephedra altissima, Histological study, In silico study, Aspergillus flavus, Aflatoxins

Abstract

Ephedra is a medicinal plant well known for its therapeutic properties, primarily attributed to its bioactive compounds. Recent studies have highlighted its antifungal potential, particularly against Aspergillus flavus, a phytopathogenic fungus responsible for aflatoxin production. However, studies on this topic remain limited. The present study aimed to investigate the anatomical adaptations of Ephedra altissima stems and to evaluate the antifungal activity of its flavonoid compounds. A detailed histological analysis was performed, complemented by an in silico study, which confirmed the strong antifungal activity of these compounds. These findings highlight the potential of Ephedra as a natural agent for managing fungal pathogens in both agriculture and healthcare. 

Bangladesh J. Bot. 54(4): 1005-1013, 2025 (December)

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Published

2025-12-30

How to Cite

Yamina, H., Faiçal, H., Imane, A., Sarra, G., & Sohayb, B. B. (2025). Investigation of ephedra altissima compounds: histological Insights and in silico targeting of dihydrofolate reductase in aspergillus flavus. Bangladesh Journal of Botany, 54(4), 1005–1013. https://doi.org/10.3329/bjb.v54i4.86576

Issue

Vol. 54 No. 4 (2025)

Section

Articles

License

© Bangladesh Botanical Society

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