Ventilator-associated pneumonia in Coronary Care Unit of a tertiary level hospital in Bangladesh: causative organisms and pattern of antibiotic sensitivity

  • Md Rezaul Karim Associate Professor, Department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh.
  • Rita Mayedah Assistant Registrar, Department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh
  • Fathima Aaysha Cader Registrar & Specialist, Department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh
Keywords: Ventilator-Associated Pneumonia (VAP), Multi drug resistant (MDR), Coronary Care Unit (CCU), invasive mechanical ventilation (IMV)

Abstract

Background: Ventilator-Associated Pneumonia (VAP) is a frequent nosocomial infection. The etiology of VAP varieswith different patient populations and types of critical care settings.

Materials & methods: This prospective observational study was conducted at the Coronary Care Unit (CCU) ofIbrahim Cardiac Hospital & Research Institute from April 2016 to November 2016. Demographic details andincidence of VAP was recorded and analysed by appropriate statistical tests.

Results: 52 patients required mechanical ventilation, of whom 19 (36.5%) developed VAP. 15 (78.9%) had early VAP,while 4 (21.2%) had late VAP. CPIS, Modified CPIS and APACHE II Score- all were significantly higher among thosewho developed VAP (p<0.01). The most frequent indication for intubation among those who developed VAP was type Irespiratory failure (57.9%), type II respiratory failure (15.8%) and post-cardiac arrest (26.3%). Acinetobacter (31.6%)was the commonest organism isolated on tracheal aspirate, followed by Pseudomonas (21.05%), Candida (21.05%)and Klebsiella (10.5%). Acinetobacter, Klebsiella and MRSA were the organisms isolated from tracheal aspirates ofthose with late onset VAP. Acinetobacter was mostly sensitive to Colistin, 80% of Pseudomonas is also sensitive tosame. A number of organisms were resistant to Amikacin and Imipenem.

Conclusion: The commonest organism responsible for VAP in our CCU was Acinetobacter, which was largely sensitiveto Colistin. The emergence of antibiotic resistance of microorganisms causing VAP is a matter of serious concern inthis study. Regular surveillance of antibiotic susceptibility pattern is very important to prevent multi-resistant bacterialinfections.

Bangladesh Crit Care J September 2019; 7(2): 73-76

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Abstract
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Published
2019-10-08
How to Cite
Karim, M. R., Mayedah, R., & Cader, F. A. (2019). Ventilator-associated pneumonia in Coronary Care Unit of a tertiary level hospital in Bangladesh: causative organisms and pattern of antibiotic sensitivity. Bangladesh Critical Care Journal, 7(2), 73-76. https://doi.org/10.3329/bccj.v7i2.43454
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Original Articles