Superior Mesenteric venous thrombosis in a patient with protein C deficiency

Authors

  • Tamzeed Hossain Post graduate student, FCPS-Part-II course (Internal Medicine), MD-Part-II-(Gastroenterology), Senior House officer, Department of Gastroenterology, United hospital limited, Gulshan-02, Dhaka
  • Nazmun Nahar Munny Post graduate student, M-Phil-part-I-(Microbiology), Dhaka Medical College, Dhaka
  • Chowdhury Rifat Niger Specialist, Department of Gastroenterology, United hospital limited, Gulshan-02, Dhaka
  • Arman Hossain Senior House officer, Department of Gastroenterology, United hospital limited, Gulshan-02, Dhaka
  • Rawshan Arra Khanam Junior consultant (Pulmonology), United hospital limited, Gulshan-02, Dhaka
  • Afsana Begum Consultant (Internal Medicine), United hospital limited, Gulshan-02, Dhaka

DOI:

https://doi.org/10.3329/bccj.v6i1.36613

Keywords:

Superior mesenteric vein (SMV), Mesenteric venous thrombosis (MVT), Protein C deficiency, Protein S deficiency, Antithrombin III deficiency, Intestinal infarction

Abstract

Mesenteric venous thrombosis causing small-bowel infarction is an extremely rare cause of acute abdomen and often difficult to diagnose. Both congenital and acquired causes are responsible. Protein C deficiency is a rare genetic abnormality that predisposes the patient to thrombophilia and leads to thrombosis, often at unusual sites. It mimics clinically with many differentials.1 This paper presents a case of superior mesenteric venous thrombosis caused by protein C deficiency, which is a rare disease. A 68-year-old foreigner female presented with complaints of constant, diffuse abdominal pain of 7 days associated with nausea, vomiting, and anorexia. Even with all sorts of conservative management, pain was not subsiding. Contrasted computed tomography of the abdomen revealed SMV thrombosis. Immediate anticoagulant was started & hypercoagulability workup revealed protein C deficiency. It is concluded that the mesenteric venous thrombosis might be caused by underlying protein C deficiency, while protein S and antithrombin III levels were normal.

Bangladesh Crit Care J March 2018; 6(1): 50-53

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Published

2018-05-09

How to Cite

Hossain, T., Munny, N. N., Niger, C. R., Hossain, A., Khanam, R. A., & Begum, A. (2018). Superior Mesenteric venous thrombosis in a patient with protein C deficiency. Bangladesh Critical Care Journal, 6(1), 50–53. https://doi.org/10.3329/bccj.v6i1.36613

Issue

Section

Case Reports