Antithrombotic potential of Berberis calliobotrys extract

Authors

DOI:

https://doi.org/10.3329/bjp.v11i4.27054

Keywords:

Antithrombotic, Berberis calliobotrys

Abstract

This study was focused with the aim to investigate the antithrombotic potential of Berberis calliobotrys. Aqueous-methanolic extract and various fractions showed significant (p<0.05-0.001) increase in prothrombin, activated partial thromboplastin and clotting time while only aqueous methanolic extract caused clot lysis when added to the blood samples of rabbit and human. In vivo study in rabbits, butanolic fraction (100 mg/kg) produced more significant prolongation in bleeding, prothrombin, activated partial thromboplastin and clotting time. Interestingly butanolic fraction had shown more pronounced effects among all tested extracts both in vivo and in vitro studies. Hence, it was subjected to antilipid peroxidation and phytochemical studies (total falvonoid contents, HPLC-DAD profile, FTIR). In conclusion, B. calliobotrys induce transient changes in the coagulation parameters, may it possess active constituents responsible for its antithrombotic potential.

Video Clips of Methodology:

Clotting time: 1 min 8 sec   Full Screen   Alternative

Prothrombin time: 2 min 43 sec   Full Screen   Alternative

Downloads

Download data is not yet available.
Abstract
1898
Download
921 Read
842

Author Biographies

. Alamgeer, Department of Pharmacology, Faculty of Pharmacy, The University of Sargodha, Sargodha, Punjab

Assistant Professor

Hira Asif, Department of Pharmacology, Faculty of Pharmacy, The University of Sargodha, Sargodha, Punjab

Phd Scholar

Shahid Rasool, Department of Pharmacology, Faculty of Pharmacy, The University of Sargodha, Sargodha, Punjab

Assistant Professor

Downloads

Additional Files

Published

2016-10-01

How to Cite

Alamgeer, ., H. Asif, and S. Rasool. “Antithrombotic Potential of Berberis Calliobotrys Extract”. Bangladesh Journal of Pharmacology, vol. 11, no. 4, Oct. 2016, pp. 776-83, doi:10.3329/bjp.v11i4.27054.

Issue

Vol. 11 No. 4 (2016)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).