Phytochemical screening and diuretic activity of Euphorbia granulata

Authors

DOI:

https://doi.org/10.3329/bjp.v10i3.22844

Keywords:

Diuretic, Euphorbia granulata

Abstract

The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of Euphorbia granulate in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p<0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p<0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.

 

Downloads

Download data is not yet available.
Abstract
1661
Download
816 Read
1140

Author Biographies

Hammad Saleem, Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan

Lecturer

M. Shoaib Ali Gill, Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan

Lecturer

Downloads

Additional Files

Published

2015-07-07

How to Cite

Saleem, H., I. Ahmad, and M. S. A. Gill. “Phytochemical Screening and Diuretic Activity of Euphorbia Granulata”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 584-7, doi:10.3329/bjp.v10i3.22844.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).