Impact of Age on Ovarian Response and IVF Outcome during Controlled Ovarian Hyperstimulation in Women from Gaza Strip

  • Maged M. Yassin The Islamic University of Gaza, Gaza Strip
  • Abdel Monem H. Lubbad The Islamic University of Gaza, Gaza Strip
  • Mohammed M. Laqqan The Islamic University of Gaza, Gaza Strip
  • Eman S. Alzmaily Al-Basma Fertility Center
Keywords: Female age, Ovarian response, In vitro fertilization outcome, Gaza Strip

Abstract

Background: Although age is an important factor in female fertility, not much date were focused on the relationship between age and ovarian response and in vitro fertilization (IVF) outcome. However, the female reproductive capacity varies with age.

Objective: To assess the impact of age on ovarian response and IVF outcome during controlled ovarian hyperstimulation in women from Gaza Strip.

Methods: This prospective cohort study consisted of 75 women attending IVF at Al-Basma Fertility Center in Gaza City. The number of oocytes and embryos were recorded for each female and the occurrence of pregnancy was followed for three months. The obtained data were computer analyzed using SPSS statistical package version 18.

Results: The mean age of the study population was 29.2±5.9 years. The total number of oocytes was significantly decreased with increasing age (F=3.932 and P=0.024).In this context Pearson correlation test exhibited negative significant correlation between women age and the number of mature oocyte (r=-0.276, P=0.017). There was an inverse relationship between age and ovarian response (F=6.773 and P=0.001), showing good response (9-16 oocytes) at mean age of 26.7±5.0 years. When related to women age, IVF outcome showed that the chance of getting pregnant increased with decreased age (F=4.278 and p= 0.018).

Conclusion: The ovarian response and the chance of getting pregnancy were diminishing with ageing, implying that maternal age should by consider during IVF program.

DOI: http://dx.doi.org/10.3329/jom.v15i1.19858

J Medicine 2014; 15: 36-40

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Author Biographies

Maged M. Yassin, The Islamic University of Gaza, Gaza Strip

Professor of Physiology at Faculty of Medicine

Abdel Monem H. Lubbad, The Islamic University of Gaza, Gaza Strip

Associate Professor of Pathology at Faculty of Medicine

Mohammed M. Laqqan, The Islamic University of Gaza, Gaza Strip

Lecturer at Faculty of Medicine

Eman S. Alzmaily, Al-Basma Fertility Center

Technologist

Published
2014-08-05
How to Cite
Yassin, M. M., Lubbad, A. M. H., Laqqan, M. M., & Alzmaily, E. S. (2014). Impact of Age on Ovarian Response and IVF Outcome during Controlled Ovarian Hyperstimulation in Women from Gaza Strip. Journal of Medicine, 15(1), 36-40. https://doi.org/10.3329/jom.v15i1.19858
Section
Original Articles