TY - JOUR AU - Sarkar, Anindita AU - Asafudullah, SM AU - Badruddoza, Shah Md AU - Sultana, Rebeka AU - Sarkar, Sunandita AU - Sarker, Sujit Kumar PY - 2022/08/10 Y2 - 2024/03/29 TI - Expression of CK-19 Immunomarker in Thyroid Neoplasm and its Association with Histopathology JF - TAJ: Journal of Teachers Association JA - TAJ: J of Teachers Assoc VL - 35 IS - 1 SE - Original Articles DO - 10.3329/taj.v35i1.61132 UR - https://www.banglajol.info/index.php/TAJ/article/view/61132 SP - 1-6 AB - <p><strong>Background &amp; Objective</strong>: Early and accurate diagnosis of thyroid neoplasm is of utmost significance for prolongation of patient survival. A panel of immunomarkers has been tested to overcome the limitation of histopathology. CK-19 is a commonly used immunomarker among them. This study was undertaken to evaluate the diagnostic accuracy of CK-19 in thyroid neoplasm.</p><p><strong>Methods &amp; Materials</strong>: This cross-sectional study was conducted in the Department of Pathology, Rajshahi Medical College, over a period of two years, from July 2017 to June 2019. A total of 44 tissue blocks of histologically confirmed thyroid neoplasm were included in this study. Then immunohistochemistry was done for CK-19 from a significant paraffin-embedded block.</p><p><strong>Result</strong>: In the present study, diffuse and strong positivity of CK-19 was found in papillary thyroid carcinoma (PTC), followed by focal positivity in follicular(FC) and medullary carcinoma (MC). A negative staining pattern was found in all cases of follicular adenoma (FA). The sensitivity and specificity of CK-19 were found to be high in the case of PTC, respectively, 88% and 92%.CK-19 expression was highly specific in differentiating malignant from benign thyroid tumors (100%).</p><p><strong>Conclusion</strong>: The study concluded that CK 19 is a highly sensitive and specific marker in papillary thyroid carcinoma. Diffuse and strong positivity is characteristic of PTC, which can be used in diagnosis with equivocal morphological appearance.</p><p>TAJ 2022; 35: No-1: 01-06</p> ER -