TY - JOUR AU - Ahmed, Tajnin AU - Islam, Muhammad Shahidul AU - Haque, Tasnuva AU - Abusyed, Mohammad PY - 2010/08/12 Y2 - 2024/03/29 TI - The Effect of Manufacturing Methods and Different Shapes on the Release Pattern of Diclofenac Sodium Matrix Tablet JF - Stamford Journal of Pharmaceutical Sciences JA - S.J. Pharm. Sci VL - 2 IS - 2 SE - Research Articles DO - 10.3329/sjps.v2i2.5828 UR - https://www.banglajol.info/index.php/SJPS/article/view/5828 SP - 76-80 AB - In the present study sustained release diclofenac sodium matrix tablets were prepared using Kollidon SR <br />polymer. Hydroxypropyl methylcellulose (HPMC 15 cps) and poly ethylene glycol (PEG-600) polymers <br />respectively were used in formulating tablets prepared by direct compression and wet granulation methods. <br />The polymers were used to explore the release pattern of the drug into the dissolution media. The tablets <br />were also prepared in various shapes (caplet oval, round oval and flat oval). A comparatively higher release <br />rate of drug was obtained from the polymer HPMC 15 cps at 10% concentration for directly compressed <br />matrix tablet than those containing 20% of HPMC after a definite period of time. In wet granulation process, <br />10% PEG-600 containing tablets showed a better release than those containing 20% PEG. The drug release <br />was also found to be sustained in case of wet granulation method than that of the direct compression method. <br />Again the caplet shaped tablets in case of direct compression method showed better release rate of drug than <br />those of the round oval and flat oval shaped tablets. Thus the result of this study shows that the proper <br />selection of the percentage of polymer and the suitable shape of tablet and proper manufacturing method can <br />provide a greater opportunity in designing sustained release dosage forms. <br /><strong><br />Key words:</strong> Matrix tablet; release pattern; direct compression; wet granulation; PEG 600; Kollidon SR.<br /><br />DOI: 10.3329/sjps.v2i2.5828<br /><em><br />Stamford Journal of Pharmaceutical Sciences</em> Vol.2(2) 2009: 76-80 ER -