TY - JOUR AU - Ali, Heyam Saad AU - Aslam, Junaid AU - Rasool, Bazigah AU - Khan, Saeed Ahemad AU - Agondi, Alaa PY - 2010/08/12 Y2 - 2024/03/29 TI - Effect of raw materials on drug release from developed Ciprofloxacin tablets JF - Stamford Journal of Pharmaceutical Sciences JA - S.J. Pharm. Sci VL - 2 IS - 2 SE - Research Articles DO - 10.3329/sjps.v2i2.5819 UR - https://www.banglajol.info/index.php/SJPS/article/view/5819 SP - 8-15 AB - The present study was undertaken to assess and evaluate the effect of two parameters on tablet formulation <br />of Ciprofloxacin: a) particle size of raw material and b) storage conditions of both raw material and finished <br />product. The raw materials were two commercial products, coarse (RM1) and fine (RM2) and locally <br />produced granular form (RM3) prepared from RM2. Three tablet formulations were prepared from the raw <br />materials and designated as F1, F2 and F3. The formulation F1 were prepared from RM1, F2 from RM2 by <br />slugging and F3 from RM3 by direct compression. The raw materials and finished products were then <br />subjected to assessment of the different parameters at the time of production and after storage for three <br />month. The particle size distribution for the raw materials was found to be &lt; 100, 100 &ndash; 250 and &gt; 250 &mu;m for <br />RM2, RM1 and RM3, respectively. The moisture uptake at 25&deg;C and 4&deg;C under 75% RH was found to be the <br />highest for the fine powder raw material (RM2), however, the developed granular form RM3 showed the least <br />uptake. Moreover, F2 did not attain 80% dissolution after storage of 3 month. The F1 and F3 formulation <br />passed the dissolution test after storage of 3 month, hence, F3 showed the highest value of dissolution (82%) <br />in 30 minutes. The physicochemical properties of raw materials, storage conditions, and manufacturing <br />techniques were found to exert a great influence over the dissolution behavior of Ciprofloxacin tablet <br />formulations. <br />&nbsp;<br /><strong>Key words:</strong> Ciprofloxacin tablets; dissolution behavior; physicochemical properties; storage conditions<br /><br />DOI: 10.3329/sjps.v2i2.5819<br /><em><br />Stamford Journal of Pharmaceutical Sciences</em> Vol.2(2) 2009: 8-15 ER -