TY - JOUR AU - Dev, Shrabanti AU - Shefa, Anha Afrin AU - Mandal, Archana AU - Gayen, Projit Roy AU - Asma, Kaniz AU - Bari, Md Abdullah Al AU - Shahriar, Masum AU - Das, Asish Kumar PY - 2018/05/07 Y2 - 2024/03/28 TI - Evaluation of antioxidant and chemopreventive effect of Cocos nucifera L. JF - Jahangirnagar University Journal of Biological Sciences JA - Jahangirnagar Univ. J. Biol. Sci. VL - 6 IS - 2 SE - Original Research Articles DO - 10.3329/jujbs.v6i2.36590 UR - https://www.banglajol.info/index.php/JUJBS/article/view/36590 SP - 47-58 AB - <p>This study revealed the antioxidant and anticancer activities of the ethanolic extract of the tender fruits of <em>Cocos nucifera</em>. In antioxidant screening, IC<sub>50</sub> value was found to be 7.71μg/mlfor ascorbic acid and44.67 μg/ml for <em>C. nucifera </em>fruits. The phenolic content, total flavonoid and total tannin content were 537.89 mg GAE/100 gm, 40.69mg of QE/100 gm and 44.61 mg of GAE/100 gm of dry powder of <em>C. nucifera </em>respectively. In DMBA and croton oil-induced skin cancer in model mice,the extract significantly decreased the number, size, yield and burden of tumor when compared with carcinogenic control. The extract increased the level of natural antioxidants like GSH, SOD and Catalase. Moreover, substantial decrease in SGPT, SGOT (liver activity marker) was observed at different doses ofthe crude extract. Lipid profile of mice treated with <em>C. nucifera </em>was brought back to normal level to some extent when compared to carcinogenic control. In conclusion,<em>C. nucifera </em>fruits have antioxidant activity as well as preventive role on cancer initiation and propagation without major toxicity.</p><p>Jahangirnagar University J. Biol. Sci. <strong>6</strong>(2): 47-58, 2017 (December)</p> ER -