Effect of Ashwagandharista (Withania somnifera) on the kidney functions of male and female rats

Authors

  • Tasmina Rahman Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
  • Md Rakib Hasan Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
  • MSK Choudhuri Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

DOI:

https://doi.org/10.3329/jujbs.v8i1.42462

Keywords:

Ashwagandharishta, kidney functions, rats

Abstract

The key objective of this present study was to analyze the effect(s) of Ashwagandharishta on the kidney functions of both male and female Albino rats. Chronic toxicity tests were also done. Following treatments the rats were observed for 51 days to know the effects of Ashwagandharishta on kidney functions considering 3 parameters such as serum urea, creatinine and uric acid. Our results failed to exhibit a significant increase in serum urea level at low dose (P<0.01), medium dose (P<0.05) and at high dose (P<0.001) in male rat groups; but with female rat groups our results showed significant increase in serum urea level at three dose levels. Regarding serum creatinine level male rats and female rats showed a trend of increase in level at different dose but effects were insignificant except medium dose in male rats (P<0.05). Regarding serum uric acid level our results failed to show a significant increase irrespective of dose.

Jahangirnagar University J. Biol. Sci. 8(1): 1-7, 2019 (June)

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Published

2019-08-03

How to Cite

Rahman, T., Hasan, M. R., & Choudhuri, M. (2019). Effect of Ashwagandharista (Withania somnifera) on the kidney functions of male and female rats. Jahangirnagar University Journal of Biological Sciences, 8(1), 1–7. https://doi.org/10.3329/jujbs.v8i1.42462

Issue

Vol. 8 No. 1 (2019)

Section

Original Research Articles

License

(c) Jahangirnagar University Journal of Biological Sciences.  

Articles in the Jahangirnagar University Journal of Biological Sciences are Open Access articles published under the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.