Analgesic, anti-inflammatory, anticonvulsant and CNS effect of the ethanolic extract of Butea monosperma roots

  • Shah Md Anisul Arefin Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
  • Md Alimul Islam Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
  • Syeda Tahmina Binte Rashid Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
  • Md Abu Rayhan Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
  • Md Monir Hossen Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
  • Md Jahir Alam Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342
  • Masum Shahriar Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344
Keywords: Butea monosperma extract, analgesic, antiinflammatory, and anticanvubsive effect

Abstract

The analgesic, anti-inflammatory, anticonvulsant and CNS activities of the ethanolic extract of Butea monosperma roots were examined. The extract produced no significant inhibition of abdominal constrictions caused by acetic acid. It showed significant inhibition of the earlyphase of formalin-induced pain, also reduced the weight of granuloma induced by a cotton pellet. Moreover, the extract caused a moderate inhibition of ear swelling in mice caused by croton oil. In pentobarbital induced sleeping time test the extract slightly reduced the onset and increased the duration of sleeping. Therefore, Butea monosperma showed analgesic, antiinflammatory, mild anticonvulsant activities as well as sedative effect on CNS.

Jahangirnagar University J. Biol. Sci. 4(1): 9-18, 2015 (June)

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Author Biography

Shah Md Anisul Arefin, Department of Pharmacy. Gono Bishwabidyalay, Savar, Dhaka-1344


Published
2016-05-18
How to Cite
Arefin, S., Islam, M. A., Rashid, S., Rayhan, M. A., Hossen, M. M., Alam, M. J., & Shahriar, M. (2016). Analgesic, anti-inflammatory, anticonvulsant and CNS effect of the ethanolic extract of Butea monosperma roots. Jahangirnagar University Journal of Biological Sciences, 4(1), 9-18. https://doi.org/10.3329/jujbs.v4i1.27781
Section
Original Research Articles