Rheumatoid Factor, Anti-cyclic Citrullinated Peptide and HLA-B Locus Antigens in Psoriatic Arthritis Patients in Bangladesh

Authors

  • Devolina Bhowmik Assistant Professor, Department of Microbiology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh.
  • Manash Chandra Sarker Junior Consultant, NITOR, Dhaka, Bangladesh
  • Shirin Tarafder Professor, Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Hosne Jahan Assistant Professor, Department of Microbiology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
  • Mst Naznin Tarana Assistant Professor, Department of Microbiology, National Institute of Laboratory Medicine and Referral Centre, Dhaka, Bangladesh
  • Sabia Shahin Sultana Lecturer, Department of Microbiology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
  • Muhammad Raquib Hussain Resident Doctor, NITOR, Dhaka

DOI:

https://doi.org/10.3329/jssmc.v12i2.56892

Keywords:

Psoriatic Arthritis (PsA), Anti-Cyclic Citrullinated Peptide (anti-CCP), Rheumatoid Factor (RF), Human Leukocyte Antigen (HLA), Polymerase Chain Reaction (PCR).

Abstract

Introduction: Psoriatic arthritis (PsA) is established as a multifactorial disease resulting from a complex interplay between genetic, environmental and immunological factors. It is a seronegative arthritis but rheumatoid factor may be present in up to 15% of PsA patients Antibodies recognizing a cyclic citrullinated peptide are highly speciûc for rheumatoid arthritis (RA) but their role in PsA remains unclear. An increased prevalence of anti-CCP antibody in PsA is also reported. Study shows that HLA-DRB1 shared epitope is signiûcantly associated with the presence of anti-CCP antibody in PsA patients but this type of association is not found with other human leukocyte antigens.

Objectives: The aim of this study was to investigate the frequency of anti-CCP and RF in PsA patients and their associations with HLA-B locus antigens.

Methods: In this cross sectional study, we selected 50 unrelated consecutive patients with PsA according to CASPAR criteria for PsA. 6 ml of blood was collected from each patient for HLAB locus typing, RA test and test for anti-CCP. Patient’s serum samples were tested for RF by Nephelometric system and tests for anti-CCP were done by ELISA. HLA-B locus typing was done by PCR with sequence specific primer.

Results: Among 50 PsA patients, 27 (54%) are female and 23 (46%) are male. RA test is positive in 10 (20%) patients and anti-CCP is positive in 7 (14%) patients. Significant association was found between HLA-B*37 and RF (p value= < 0.001).

Conclusion: RF is present in 10 (20%) and anti-CCP is present in 7 (14%) PsA patients. HLAB* 37 was significantly found in RF positive patients.

J Shaheed Suhrawardy Med Coll 2020; 12(2): 109-114

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Published

2022-01-03

How to Cite

Bhowmik, D. ., Sarker, M. C. ., Tarafder, S. ., Jahan, H., Tarana, M. N. ., Sultana, S. S. ., & Hussain, M. R. . (2022). Rheumatoid Factor, Anti-cyclic Citrullinated Peptide and HLA-B Locus Antigens in Psoriatic Arthritis Patients in Bangladesh. Journal of Shaheed Suhrawardy Medical College, 12(2), 109–114. https://doi.org/10.3329/jssmc.v12i2.56892

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