Lymphangitic Carcinomatosis of Unknown Primary: A Case Report

Authors

  • Md. Abu Shahin Assistant Professor, Department of Rheumatology, Banghabondhu Sheik Mujib Medical University, Dhaka
  • Matiur Rahman Senior House Officer, United Hospital, Dhaka
  • Gourab Dewan Junior Consultant, Rangamati General Hospital, Rangamati
  • Atia Saeed Resident, Department of Gastroenterology, Banghabondhu Sheik Mujib Medical University, Dhaka
  • M. Nahiduzzaman Shazzad Medical Officer, Department of Rheumatology, Banghabondhu Sheik Mujib Medical University, Dhaka
  • M.R. Chowdhury Professor, Department of Rheumatology, Banghabondhu Sheik Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/jssmc.v5i2.20769

Keywords:

Pulmonary, lymphangitic carcinomatosis, metastasis, PLC

Abstract

Lymphangitic carcinomatosis is an uncommon manifestation of metastasis to lung. Its presentation can mimic several disorders of the lungs. A case is presented here where patient presented with progressive dyspnoea, dry cough, weight loss and fever. The patient was amenorrheic for the last 2 years. Her physical findings were unremarkable initially other than the weight loss and evidence of pulmonary hypertension. Subsequently her dyspnoea rapidly worsened and the patient became bed bound. Investigations revealed neutrophilic leucocytosis, normal Hb with high ESR. ANA, anti Cetromere and anti Scl 70 was negative. Serum  calcium  was  normal.  Liver  function  test  was  normal  other  than  raised  alkaline  phosphatase. Tuberculin test was negative. Chest X-ray revealed increased bilateral symmetrical streaks and reticulation with peripheral and lower distribution which is consistent with pulmonary lymphangitic carcinomatosis. HRCT of Lungs has shown diffuse infiltrations, reticulo-nodular and ground glass opacities, centrilobular emphysema with accentuation of broncho-vascular densities in both lung fields. There were enlarged mediastinal lymph nodes, bilateral pleural effusion. Doppler Echo revealed mild pulmonary hypertension with fair EF. Tumor markers were done. CA125, CA 19.9 and AFP were ten times higher than normal. Fibreoptic nasopharyngoesophagoscopy was normal. Diagnosis of PLC was made on clinical feature, radiological finding and elevated tumor markers. Symptomatic treatment was given during the period of evaluation. Ultimately the patient succumbed to death.

DOI: http://dx.doi.org/10.3329/jssmc.v5i2.20769

J Shaheed Suhrawardy Med Coll, 2013;5(2):114-116

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Published

2013-12-01

How to Cite

Shahin, M. A., Rahman, M., Dewan, G., Saeed, A., Shazzad, M. N., & Chowdhury, M. (2013). Lymphangitic Carcinomatosis of Unknown Primary: A Case Report. Journal of Shaheed Suhrawardy Medical College, 5(2), 114–116. https://doi.org/10.3329/jssmc.v5i2.20769

Issue

Section

Case Reports